3,4-dihydro-1H-1-benzazepine-2,5-dione 5-[N-(4-nitrophenyl)hydrazone] -Drug Synthesis Database

【结构式】

【分子编号】34401

【品名】3,4-dihydro-1H-1-benzazepine-2,5-dione 5-[N-(4-nitrophenyl)hydrazone]

【CA登记号】

【分子式】C₁₆H₁₄N₄O₃

【分子量】310.31232

【元素组成】C 61.93% H 4.55% N 18.06% O 15.47%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(III)

The condensation of p-nitrophenylhydrazine (I) with benzazepinedione (II) in AcOH produced hydrazone (III). Subsequent Fischer indole synthesis employing (III) and H2SO4 furnished the title indolobenzazepinone.

参考文献中间体

合成目标

【1】 Schultz, C.; Zaharevitz, D.W.; Mejer, L.; Gussio, R.; Leost, M.; Sausville, E.A.; Kunick, C.; Link, A.; Paullones, a series of cyclin-dependent kinase inhibitors: Synthesis, evaluation of CDK1/cyclin B inhibition, and in vitro antitumor activity. J Med Chem 1999, 42, 15, 2909.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	34400	1-(4-nitrophenyl)hydrazine; 4-Nitrophenylhydrazine	100-16-3	C₆H₇N₃O₂	详情	详情
(II)	18879	3,4-dihydro-1H-1-benzazepine-2,5-dione		C₁₀H₉NO₂	详情	详情
(III)	34401	3,4-dihydro-1H-1-benzazepine-2,5-dione 5-[N-(4-nitrophenyl)hydrazone]		C₁₆H₁₄N₄O₃	详情	详情

Extended Information