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【结 构 式】 
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【分子编号】34382 【品名】(3S,10R,16S)-10-(4-amino-3-chlorobenzyl)-3-isobutyl-6,6-dimethyl-16-[(1R)-1-[(2R,3S)-3-phenyloxiranyl]ethyl]-1,4-dioxa-8,11-diaza-13-cyclohexadecene-2,5,9,12-tetrone 【CA登记号】 |
【 分 子 式 】C35H44ClN3O7 【 分 子 量 】654.20308 【元素组成】C 64.26% H 6.78% Cl 5.42% N 6.42% O 17.12% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(XVI)Further epoxidation of (XIV) with m-CPBA led to a mixture of alpha and beta diastereomeric epoxides, which were separated by RP-HPLC to afford the major beta-epoxide (XV). Deprotection of (XV) with piperidine gave aniline (XVI). This was finally alkylated using iodomethane in the presence of K2CO3 to produce the title dimethylamine.
| 【1】 Schultz, R.M.; Andis, S.L.; Ray, J. E.; Patel, V.F.; Kennedy, J.H.; Novel cryptophycin antitumor agents: Synthesis and cytotoxicity of fragment "B" analogues. J Med Chem 1999, 42, 14, 2588. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (XIV) | 34380 | 9H-fluoren-9-ylmethyl 2-chloro-4-([(3S,10R,16S)-3-isobutyl-6,6-dimethyl-16-[(1R,2E)-1-methyl-3-phenyl-2-propenyl]-2,5,9,12-tetraoxo-1,4-dioxa-8,11-diaza-13-cyclohexadecen-10-yl]methyl)phenylcarbamate | C50H54ClN3O8 | 详情 | 详情 | |
| (XV) | 34381 | 9H-fluoren-9-ylmethyl 2-chloro-4-[((3S,10R,16S)-3-isobutyl-6,6-dimethyl-2,5,9,12-tetraoxo-16-[(1R)-1-[(2R,3S)-3-phenyloxiranyl]ethyl]-1,4-dioxa-8,11-diaza-13-cyclohexadecen-10-yl)methyl]phenylcarbamate | C50H54ClN3O9 | 详情 | 详情 | |
| (XVI) | 34382 | (3S,10R,16S)-10-(4-amino-3-chlorobenzyl)-3-isobutyl-6,6-dimethyl-16-[(1R)-1-[(2R,3S)-3-phenyloxiranyl]ethyl]-1,4-dioxa-8,11-diaza-13-cyclohexadecene-2,5,9,12-tetrone | C35H44ClN3O7 | 详情 | 详情 |
Extended Information