• English
  • 简体中文
Login Register
Current Location: Home > Feedback Help Print

【结 构 式】

【分子编号】33898

【品名】2-[benzyl(methyl)amino]ethyl 3-oxobutanoate

【CA登记号】

【 分 子 式 】C14H19NO3

【 分 子 量 】249.3098

【元素组成】C 67.45% H 7.68% N 5.62% O 19.25%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(III)

Compound can be prepared in two different ways: 1) By heating at 100 C a mixture of m-nitrobenzaldehyde (I), methyl beta-aminocrotonate (II) and N-benzyl-N-methylaminoethyl acetoacetate (III). 2) By cyclization of a mixture of m-nitrobenzaldehyde (I), methyl acetoacetate (IV) and N-benzyl-N-methylaminoethyl beta + aminocrotonate (V) in refluxing isopropanol.

1 Murakami, M.; et al.; BE 0811324 .
2 Roberts, P.J.; Castaner, J.; YC-93. Drugs Fut 1977, 2, 6, 409.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 12646 3-Nitrobenzaldehyde 99-61-6 C7H5NO3 详情 详情
(II) 11372 Methyl (E)-3-amino-2-butenoate; Methyl 3-aminocrotonate C5H9NO2 详情 详情
(III) 33898 2-[benzyl(methyl)amino]ethyl 3-oxobutanoate C14H19NO3 详情 详情
(IV) 11791 methyl 3-oxobutanoate; Methyl acetoacetate 105-45-3 C5H8O3 详情 详情
(V) 33899 2-[benzyl(methyl)amino]ethyl (E)-3-amino-2-butenoate C14H20N2O2 详情 详情
Extended Information