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【结 构 式】 
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【分子编号】28278 【品名】(2S)-5-[benzyl(2-[[(2,5-diphenyl-1,3-oxazol-4-yl)carbonyl]amino]ethyl)amino]-2-(decanoylamino)-5-oxopentanoic acid 【CA登记号】 |
【 分 子 式 】C40H48N4O6 【 分 子 量 】680.84448 【元素组成】C 70.57% H 7.11% N 8.23% O 14.1% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(XIII)Amine (XI) was coupled to isoxazolecarboxylic acid (XII) to give (XIII). which was finally liberated from the resin by cleavage with trifluoroacetic acid in CH2Cl2.
| 【1】 Wipf, P.; et al.; Combinatorial synthesis and biological evaluation of library of small-molecule Ser/Thr-protein phosphatase inhibitors. Bioorg Med Chem 1997, 5, 1, 165. |
| 【2】 Lazo, J.S.; Rice, R.L.; Cunningham, A.; Wipf, P. (University of Pittsburgh); Phosphatase inhibitors and methods of use thereof. EP 0959884; US 5700821; WO 9804257 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (XI) | 28276 | (2S)-5-[(2-aminoethyl)(benzyl)amino]-2-(decanoylamino)-5-oxopentanoic acid | C24H39N3O4 | 详情 | 详情 | |
| (XII) | 28277 | 2,5-diphenyl-1,3-oxazole-4-carboxylic acid | C16H11NO3 | 详情 | 详情 | |
| (XIII) | 28278 | (2S)-5-[benzyl(2-[[(2,5-diphenyl-1,3-oxazol-4-yl)carbonyl]amino]ethyl)amino]-2-(decanoylamino)-5-oxopentanoic acid | C40H48N4O6 | 详情 | 详情 |
Extended Information