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【结 构 式】

【分子编号】28239

【品名】ethyl (E)-4-bromo-2-butenoate

【CA登记号】37746-78-4

【 分 子 式 】C6H9BrO2

【 分 子 量 】193.04026

【元素组成】C 37.33% H 4.7% Br 41.39% O 16.58%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(XXVIII)

Synthesis of intermediate (XXX) of Scheme 25142902e: Alkylation of piperidine (XXVII) with ethyl 4-bromocrotonate (XXVIII) afforded tertiary amine (XXIX). Acid hydrolysis of the ethyl ester of (XXIX) then provided carboxylic acid (XXX).

1 Dowle, M.D.; Finch, H.; Harrison, L.A.; Inglis, G.G.A.; Johnson, M.R.; Macdonald, S.J.F.; Shah, P.; Smith, R.A. (Glaxo Wellcome plc); Pyrrolopyrrolone derivs. as inhibitors of neutrophil elastase. EP 0891362; JP 2000507950; US 5994344; WO 9736903 .
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(XXVII) 10158 Piperidine 110-89-4 C5H11N 详情 详情
(XXVIII) 28239 ethyl (E)-4-bromo-2-butenoate 37746-78-4 C6H9BrO2 详情 详情
(XXIX) 28240 ethyl (E)-4-(1-piperidinyl)-2-butenoate C11H19NO2 详情 详情
(XXX) 26709 (E)-4-(1-piperidinyl)-2-butenoic acid;(E)-4-(piperidin-1-yl)but-2-enoic acid C9H15NO2 详情 详情
Extended Information