【结 构 式】 |
【分子编号】28164 【品名】2-hydroxy-5-iodo-3-methylbenzaldehyde 【CA登记号】 |
【 分 子 式 】C8H7IO2 【 分 子 量 】262.04685 【元素组成】C 36.67% H 2.69% I 48.43% O 12.21% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号:(II)The 5-methylsalicylaldehyde (I) is prepared by a tin (IV) chloride-catalyzed formylation. Iodination of the aldehyde with ICl in glacial acetic acid gives good yield of 3-methyl-5-iodobenzylaldehyde (III). The iodinated salicylaldehyde is reductively aminated with N,N,N'-trimethylpropane-1,3-diamine and sodium borohydride to give N,N,N'-trimethyl-N'-(2-hydroxy-3-methyl-5-iodobenzyl)-1,3-propanediamine (HIPDM) (III) in excellent yield.
【1】 Blau, M.; Tramposch, K.M.; Kung, H.F.; Radioiodine-labeled N,N-dimethyl-N'-(2-hydroxy-3-ankyl-5-iodobenzyl)-1,3.propanediamines for Brain Perfusion Imaging. J Med Chem 1983, 28, 2, 121-125. |
【2】 Kung, H.F.; Hostyniak, P.J.; HIPDM. Drugs Fut 1985, 10, 9, 742. |
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