【结 构 式】 |
【分子编号】28132 【品名】methyl (2S)-3-[(tert-butoxycarbonyl)amino]-2-[[(3-methylphenyl)sulfonyl]amino]propanoate 【CA登记号】 |
【 分 子 式 】C16H24N2O6S 【 分 子 量 】372.44244 【元素组成】C 51.6% H 6.5% N 7.52% O 25.77% S 8.61% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号:(III)Preparation of intermediate (IV) is illustrated in Scheme 25654801a: Methyl N3-Boc-(S)-2,3-diaminopropionate (I) was condensed with m-toluenesulfonyl chloride (II) to provide sulfonamide (III). The Boc group was then deprotected with HCl in dioxan to give amine (IV).
【1】 Wityak, J.; Xue, C.-B.; Sielecki-Dzurdz, T.M.; Olson, R.E.; Degrado, W.F.; Cain, G.A. (DuPont Pharmaceuticals Co.); Novel isoxazoline and isoxazole fibrinogen receptor antagonists. EP 0730590; EP 0832076; JP 1997505590; JP 1999504651; US 5849736; WO 9514683; WO 9638426 . |
中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
---|---|---|---|---|---|---|
(I) | 25095 | methyl (2S)-2-amino-3-[(tert-butoxycarbonyl)amino]propanoate | C9H18N2O4 | 详情 | 详情 | |
(II) | 23316 | 3-methylbenzenesulfonyl chloride | 1899-93-0 | C7H7ClO2S | 详情 | 详情 |
(III) | 28132 | methyl (2S)-3-[(tert-butoxycarbonyl)amino]-2-[[(3-methylphenyl)sulfonyl]amino]propanoate | C16H24N2O6S | 详情 | 详情 | |
(IV) | 28133 | methyl (2S)-3-amino-2-[[(3-methylphenyl)sulfonyl]amino]propanoate | C11H16N2O4S | 详情 | 详情 |
Extended Information