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【结 构 式】 
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【分子编号】28084 【品名】dimethyl 2,2-dichloro-1-hydroxyvinylphosphonate 【CA登记号】 |
【 分 子 式 】C4H7Cl2O4P 【 分 子 量 】220.976342 【元素组成】C 21.74% H 3.19% Cl 32.09% O 28.96% P 14.02% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(I)Metrifonate is totally unique among the acetylcholinesterase inhibitors currently used or proposed for the treatment of Alzheimer's disease because it is an inactive prodrug. The active compound dichlorvos, (2,2-dichlorovinyl dimethylphosphate; DDVP), is formed in a nonenzymatic reaction by hydrolysis and elimination of HCl followed by rearrangement of an intermediate according to Scheme.
| 【1】 Mucke, H.A.M.; Metrifonate. Drugs Fut 1998, 23, 5, 491. |
| 【2】 Giang, P.A.; Barthel, W.F.; Hall, S.A.; Dialkylalpha-hydroxyphosphonates derived from chloral. J Am Chem Soc 1954, 76, 4186-7. |
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