【结 构 式】 |
【分子编号】28076 【品名】1-(3-chloro-1-phenylpropoxy)-2-(methylsulfanyl)benzene 【CA登记号】 |
【 分 子 式 】C16H17ClOS 【 分 子 量 】292.82908 【元素组成】C 65.63% H 5.85% Cl 12.11% O 5.46% S 10.95% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号:(IV)Reduction of 3-chloropropiophenone (I) with NaBH4 produced 3-chloro-1-phenyl-1-propanol (II). Subsequent Mitsunobu coupling of (II) with 2-(methylthio)phenol (III) in the presence of DEAD and PPh3 afforded ether (IV). Finally, substitution of the halogen of (IV) for methylamine provided the corresponding secondary amine.
【1】 Gehlert, D.R.; Robertson, D.W.; Wong, D.T. (Eli Lilly and Company); N-Alkyl-3-phenyl-3-(2-alkylthiophenoxy)propylamines. EP 0591581 . |
中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
---|---|---|---|---|---|---|
11021 | Methanamine; Methylamine | 74-89-5 | CH5N | 详情 | 详情 | |
(I) | 28073 | 3-chloro-1-phenyl-1-propanone | 936-59-4 | C9H9ClO | 详情 | 详情 |
(II) | 28074 | 3-chloro-1-phenyl-1-propanol | C9H11ClO | 详情 | 详情 | |
(III) | 28075 | 2-(methylsulfanyl)phenol | 1073-29-6 | C7H8OS | 详情 | 详情 |
(IV) | 28076 | 1-(3-chloro-1-phenylpropoxy)-2-(methylsulfanyl)benzene | C16H17ClOS | 详情 | 详情 |
Extended Information