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【结 构 式】

【分子编号】28076

【品名】1-(3-chloro-1-phenylpropoxy)-2-(methylsulfanyl)benzene

【CA登记号】

【 分 子 式 】C16H17ClOS

【 分 子 量 】292.82908

【元素组成】C 65.63% H 5.85% Cl 12.11% O 5.46% S 10.95%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(IV)

Reduction of 3-chloropropiophenone (I) with NaBH4 produced 3-chloro-1-phenyl-1-propanol (II). Subsequent Mitsunobu coupling of (II) with 2-(methylthio)phenol (III) in the presence of DEAD and PPh3 afforded ether (IV). Finally, substitution of the halogen of (IV) for methylamine provided the corresponding secondary amine.

1 Gehlert, D.R.; Robertson, D.W.; Wong, D.T. (Eli Lilly and Company); N-Alkyl-3-phenyl-3-(2-alkylthiophenoxy)propylamines. EP 0591581 .
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
11021 Methanamine; Methylamine 74-89-5 CH5N 详情 详情
(I) 28073 3-chloro-1-phenyl-1-propanone 936-59-4 C9H9ClO 详情 详情
(II) 28074 3-chloro-1-phenyl-1-propanol C9H11ClO 详情 详情
(III) 28075 2-(methylsulfanyl)phenol 1073-29-6 C7H8OS 详情 详情
(IV) 28076 1-(3-chloro-1-phenylpropoxy)-2-(methylsulfanyl)benzene C16H17ClOS 详情 详情
Extended Information