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【结 构 式】 
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【分子编号】27982 【品名】S-[4,4-bis(diisopropoxyphosphoryl)butyl] ethanethioate 【CA登记号】 |
【 分 子 式 】C18H38O7P2S 【 分 子 量 】460.509044 【元素组成】C 46.95% H 8.32% O 24.32% P 13.45% S 6.96% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(III)Tetraisopropyl methylenediphosphonate (I) was alkylated with 3-(acetylthio)propyl iodide (II) in the presence of NaH to give (III). Then, hydrolysis of both thioester and phosphonate esters of (III) with refluxing HCl provided the intermediate thiol (IV).
| 【1】 Gil, L.; et al.; Prostaglandin E2-bisphosphonate conjugates: Potential agents for treatment of osteoporosis. Bioorg Med Chem 1999, 7, 5, 901. |
| 【2】 Gil, L.; Young, R.N.; Ruel, R.; Han, Y. (Merck Frosst Canada Inc.); Prostaglandin conjugates for treating or preventing bone disease. US 6121253; WO 0031084 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 27980 | Diisopropyl (diisopropoxyphosphoryl)methylphosphonate; Tetraisopropyl methylenediphosphonate | 1660-95-3 | C13H30O6P2 | 详情 | 详情 |
| (II) | 27981 | S-(3-iodopropyl) ethanethioate | C5H9IOS | 详情 | 详情 | |
| (III) | 27982 | S-[4,4-bis(diisopropoxyphosphoryl)butyl] ethanethioate | C18H38O7P2S | 详情 | 详情 | |
| (IV) | 27983 | 1-phosphono-4-sulfanylbutylphosphonic acid | C4H12O6P2S | 详情 | 详情 |
Extended Information