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【结 构 式】

【分子编号】27974

【品名】Benzhydrylchloride; 1,1-Diphenylchloromethane; Dibenzyl chloride; Alpha-Chlorodiphenylmethane; Chlorodiphenylmethane; Diphenylchloromethane; 1-[chloro(phenyl)methyl]benzene

【CA登记号】90-99-3

【 分 子 式 】C13H11Cl

【 分 子 量 】202.68304

【元素组成】C 77.04% H 5.47% Cl 17.49%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(IV)

Condensation of trimethylhydroquinone (I) with 4-chloro-1-butanol (II) in the presence of phosphomolybdic acid in refluxing toluene yielded the chlorobutyl ether (III). Benzhydrylpiperazine (VI), (prepared from chlorodiphenylmethane (IV) and piperazine (V)), was then condensed with chloride (III) to give the target compound, which was isolated as the dihydrochloride salt.

1 Kawasaki, N.; Satoh, T.; Nagai, H.; Nishiki, M.; Matsumoto, H.; Inagaki, N.; Miyataka, H.; Synthesis of trimethylhydroquinone derivatives as anti-allergic agents with anti-oxidative actions. Chem Pharm Bull 1999, 47, 2, 177.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 26357 2,3,5-trimethyl-1,4-benzenediol 700-13-0 C9H12O2 详情 详情
(II) 22336 4-chloro-1-butanol 928-51-8 C4H9ClO 详情 详情
(III) 27973 4-(4-chlorobutoxy)-2,3,6-trimethylphenol C13H19ClO2 详情 详情
(IV) 27974 Benzhydrylchloride; 1,1-Diphenylchloromethane; Dibenzyl chloride; Alpha-Chlorodiphenylmethane; Chlorodiphenylmethane; Diphenylchloromethane; 1-[chloro(phenyl)methyl]benzene 90-99-3 C13H11Cl 详情 详情
(V) 10355 Diethylenediamine; Piperazine 110-85-0 C4H10N2 详情 详情
(VI) 20796 N-(Benzhydryl)piperazine; 1-Benzhydrylpiperazine; 1-(dibenzyl)piperazine 841-77-0 C17H20N2 详情 详情
Extended Information