N-(2-aminoethyl)-N-(5-methoxy-1,2,3,4-tetrahydro-2-naphthalenyl)-N-propylamine -Drug Synthesis Database

【结构式】

【分子编号】27939

【品名】N-(2-aminoethyl)-N-(5-methoxy-1,2,3,4-tetrahydro-2-naphthalenyl)-N-propylamine

【CA登记号】

【分子式】C₁₆H₂₆N₂O

【分子量】262.39532

【元素组成】C 73.24% H 9.99% N 10.68% O 6.1%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(III)

Alkylation of aminotetralin (I) with bromoacetonitrile in boiling acetone gave cyanomethyl compound (II). This was subsequently reduced to diamine (III) using LiAlH4. Condensation of (III) with benzoyl chloride under Schotten-Baumann conditions then yielded the corresponding benzamide.

参考文献中间体

合成目标

【1】 Homan, E.J.; Copinga, S.; Elfström, L.; van der Veen, T.; Hallema, J.-P.; Mohell, N.; Unelius, L.; Johansson, R.; Wikström, H.V.; Grol, C.J.; 2-Aminotetralin-derived substituted benzamides with mixed dopamine D2, D3, and serotonin 5-HT1A receptor binding properties: A novel class of potential atypical antipsychotic agents. Bioorg Med Chem 1998, 6, 11, 2111.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
	10463	Benzoyl chloride	98-88-4	C₇H₅ClO	详情	详情
	31883	2-bromoacetonitrile	590-17-0	C₂H₂BrN	详情	详情
(I)	14648	N-(5-methoxy-1,2,3,4-tetrahydro-2-naphthalenyl)-N-propylamine; 5-methoxy-N-propyl-1,2,3,4-tetrahydro-2-naphthalenamine		C₁₄H₂₁NO	详情	详情
(II)	27938	2-[(5-methoxy-1,2,3,4-tetrahydro-2-naphthalenyl)(propyl)amino]acetonitrile		C₁₆H₂₂N₂O	详情	详情
(III)	27939	N-(2-aminoethyl)-N-(5-methoxy-1,2,3,4-tetrahydro-2-naphthalenyl)-N-propylamine		C₁₆H₂₆N₂O	详情	详情

Extended Information