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【结 构 式】

【分子编号】27605

【品名】methyl 2-[(tributylstannyl)methyl]acrylate

【CA登记号】

【 分 子 式 】C17H34O2Sn

【 分 子 量 】389.16576

【元素组成】C 52.47% H 8.81% O 8.22% Sn 30.5%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(LXI)

Hydrogenolysis of the benzyl ether of (LIX) and subsequent treatment with Tf2O gave aryl triflate (LX). Stille coupling reaction of (LX) with organotin reagent (LXI) produced unsaturated ester (LXII), which was then hydrogenated over Pd/C to give (LXIII). Basic hydrolysis of both ester groups of (LXIII) yielded the racemic diacid, which was finally resolved using quinidine.

1 Niiyama, K.; et al.; A potent, orally active, most balanced ETA/ETB dual endothelin receptor antagonist. Discovery of J-104132. 15th European Federation for Medicinal Chemistry International Symposium on Medicinal Chemistry (Sept 6 1998, Edinburgh) 1998, Abst P.297.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(LIX) 27603 ethyl (5S,6R,7R)-5-(1,3-benzodioxol-5-yl)-7-[2-(benzyloxy)-4-methoxyphenyl]-2-butyl-6,7-dihydro-5H-cyclopenta[b]pyridine-6-carboxylate C36H37NO6 详情 详情
(LX) 27604 ethyl (5S,6R,7R)-5-(1,3-benzodioxol-5-yl)-2-butyl-7-(4-methoxy-2-[[(trifluoromethyl)sulfonyl]oxy]phenyl)-6,7-dihydro-5H-cyclopenta[b]pyridine-6-carboxylate C30H30F3NO8S 详情 详情
(LXI) 27605 methyl 2-[(tributylstannyl)methyl]acrylate C17H34O2Sn 详情 详情
(LXII) 27606 ethyl (5S,6R,7R)-5-(1,3-benzodioxol-5-yl)-2-butyl-7-[4-methoxy-2-[2-(methoxycarbonyl)-2-propenyl]phenyl]-6,7-dihydro-5H-cyclopenta[b]pyridine-6-carboxylate C34H37NO7 详情 详情
(LXIII) 27607 ethyl (5S,6R,7R)-5-(1,3-benzodioxol-5-yl)-2-butyl-7-[4-methoxy-2-[(2S)-3-methoxy-2-methyl-3-oxopropyl]phenyl]-6,7-dihydro-5H-cyclopenta[b]pyridine-6-carboxylate C34H39NO7 详情 详情
Extended Information