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【结 构 式】 
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【分子编号】27589 【品名】isopropyl (6S,7R)-5-(1,3-benzodioxol-5-yl)-7-[2-[(2S)-3-(benzyloxy)-2-methylpropyl]-4-methoxyphenyl]-2-butyl-5-hydroxy-6,7-dihydro-5H-cyclopenta[b]pyridine-6-carboxylate 【CA登记号】 |
【 分 子 式 】C41H47NO7 【 分 子 量 】665.82672 【元素组成】C 73.96% H 7.11% N 2.1% O 16.82% |
合成路线1
该中间体在本合成路线中的序号：(XLIV)Intermediate alcohol (XI) was then protected as the benzyl ether (XLII). After its conversion to the corresponding organolithium reagent, addition to pyridine ester (XLI) produced ketone (XLIII). Finally, the title compound was obtained by a similar sequence to that from above, involving cyclization of (XLIII) to (XLIV) with sodium tert-pentoxide, deoxygenation with SmI2, hydrogenolysis of benzyl ether to give (XLV), and then oxidation of (XLV) to acid followed by isopropyl ester hydrolysis.
| 【1】 Frey, L.F.; Devine, P.N.; Tschaen, D.M.; Dolling, U.H.; Tillyer, R.D.; Kato, Y. (Banyu Pharmaceutical Co., Ltd.; Merck & Co., Inc.); Stereoselective deoxygenation reaction. EP 0923557; JP 1999514676; WO 9806700 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (XI) | 27558 | (2S)-3-(2-bromo-5-methoxyphenyl)-2-methyl-1-propanol | C11H15BrO2 | 详情 | 详情 | |
| (XLI) | 27586 | methyl 3-[(1S)-1-(1,3-benzodioxol-5-yl)-3-isopropoxy-3-oxopropyl]-6-butyl-2-pyridinecarboxylate | C24H29NO6 | 详情 | 详情 | |
| (XLII) | 27587 | 2-[(2S)-3-(benzyloxy)-2-methylpropyl]-1-bromo-4-methoxybenzene | C18H21BrO2 | 详情 | 详情 | |
| (XLIII) | 27588 | isopropyl (3S)-3-(1,3-benzodioxol-5-yl)-3-(2-[2-[(2S)-3-(benzyloxy)-2-methylpropyl]-4-methoxybenzoyl]-6-butyl-3-pyridinyl)propanoate | C41H47NO7 | 详情 | 详情 | |
| (XLIV) | 27589 | isopropyl (6S,7R)-5-(1,3-benzodioxol-5-yl)-7-[2-[(2S)-3-(benzyloxy)-2-methylpropyl]-4-methoxyphenyl]-2-butyl-5-hydroxy-6,7-dihydro-5H-cyclopenta[b]pyridine-6-carboxylate | C41H47NO7 | 详情 | 详情 | |
| (XLV) | 27590 | isopropyl (5S,6R,7R)-5-(1,3-benzodioxol-5-yl)-2-butyl-7-[2-[(2S)-3-hydroxy-2-methylpropyl]-4-methoxyphenyl]-6,7-dihydro-5H-cyclopenta[b]pyridine-6-carboxylate | C34H41NO6 | 详情 | 详情 |