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【结 构 式】 
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【分子编号】27477 【品名】tert-butyl 4-[3-[(3R)-3-([[(1S)-3-methoxy-3-oxo-1-(3-pyridinyl)propyl]amino]carbonyl)piperidinyl]-3-oxopropyl]-1-piperidinecarboxylate 【CA登记号】 |
【 分 子 式 】C28H42N4O6 【 分 子 量 】530.66484 【元素组成】C 63.37% H 7.98% N 10.56% O 18.09% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(XIII)Compound (XI) was coupled with N-Boc-3-(4-piperidinyl)propionic acid (XII) to produce diamide (XIII). Finally, hydrolysis of the methyl ester of (XIII) with LiOH, followed by acid removal of the Boc group yielded the title compound.
| 【1】 Hoekstra, W.J.; Damiano, B.P.; Maryanoff, B.E.; et al.; Potent orally active GPIIb/IIIa antagonists containing a nipecotic acid subunit. Structure - Activity studies leading to the discovery of RWJ-53308. J Med Chem 1999, 42, 25, 5254. |
| 【2】 Costanzo, M.J.; Hoekstra, W.J.; Maryanoff, B.E. (Ortho-McNeil Pharmaceutical, Inc.); Carboxamide derivs. of pyrrolidine, piperidine and hexahydroazepine for the treatment of thrombosis disorders. EP 0923555; JP 2000510111; US 6069254; WO 9741102 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (XI) | 27475 | methyl (3S)-3-[[(3R)piperidinylcarbonyl]amino]-3-(3-pyridinyl)propanoate | C15H21N3O3 | 详情 | 详情 | |
| (XII) | 27476 | 1-Boc-piperidin-4-ylpropionic acid; 3-[1-(tert-butoxycarbonyl)-4-piperidinyl]propionic acid | C13H23NO4 | 详情 | 详情 | |
| (XIII) | 27477 | tert-butyl 4-[3-[(3R)-3-([[(1S)-3-methoxy-3-oxo-1-(3-pyridinyl)propyl]amino]carbonyl)piperidinyl]-3-oxopropyl]-1-piperidinecarboxylate | C28H42N4O6 | 详情 | 详情 |
Extended Information