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【结 构 式】

【分子编号】27368

【品名】2H-1,4-benzoxazine-3(4H)-thione

【CA登记号】

【 分 子 式 】C8H7NOS

【 分 子 量 】165.21572

【元素组成】C 58.16% H 4.27% N 8.48% O 9.68% S 19.41%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(IV)

The cyclocondensation of 2H-1,4 benzoxazine-3(4H)-thione (IV) with ethyl carbazate (II) in refluxing DMF gives 2,4-dihydro[1,2,4]triazolo[3,4-c][1,4]benzoxazin-1-one (V), which is nitrated at room temperature with a mixture of concentrated HNO3 and H2SO4.

1 Shridhar, D.R.; Potential diuretics. Part I. Synthesis of some substituted 2,4-dihydro-1-oxo/thioxo-1,2,4-triazolo[3,4-c][1,4]benzoxazines - Novel diuretic agents. Indian J Chem 1984, 238, 1279.
2 Shridhar, D.R.; Arya, V.P.; IDPH-8032. Drugs Fut 1985, 10, 7, 559.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(II) 27366 Ethyl hydrazinecarboxylate; Ethyl 1-hydrazinecarboxylate 4114-31-2 C3H8N2O2 详情 详情
(IV) 27368 2H-1,4-benzoxazine-3(4H)-thione C8H7NOS 详情 详情
(V) 27369 2,4-dihydro-1H-[1,2,4]triazolo[3,4-c][1,4]benzoxazin-1-one C9H7N3O2 详情 详情
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