• English
  • 简体中文
Login Register
Current Location: Home > Feedback Help Print

【结 构 式】

【分子编号】27365

【品名】6,8-dinitro-2H-1,4-benzoxazine-3(4H)-thione

【CA登记号】

【 分 子 式 】C8H5N3O5S

【 分 子 量 】255.21092

【元素组成】C 37.65% H 1.97% N 16.46% O 31.35% S 12.56%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(I)

The reaction of 6,8-dinitro-2H-1,4-benzoxazine-3(4H)-thione (I) with ethyl carbazate (II) in refluxing ethanol gives 6,8-dinitro-3-(2-ethoxy-carbonyl)hydrazino-2H-1,4-benzoxazine (III), which undergoes ring closure in refluxing o-dichlorobenzene to give the title compound.

1 Shridhar, D.R.; Potential diuretics. Part I. Synthesis of some substituted 2,4-dihydro-1-oxo/thioxo-1,2,4-triazolo[3,4-c][1,4]benzoxazines - Novel diuretic agents. Indian J Chem 1984, 238, 1279.
2 Shridhar, D.R.; Arya, V.P.; IDPH-8032. Drugs Fut 1985, 10, 7, 559.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 27365 6,8-dinitro-2H-1,4-benzoxazine-3(4H)-thione C8H5N3O5S 详情 详情
(II) 27366 Ethyl hydrazinecarboxylate; Ethyl 1-hydrazinecarboxylate 4114-31-2 C3H8N2O2 详情 详情
(III) 27367 ethyl 2-(6,8-dinitro-2H-1,4-benzoxazin-3-yl)-1-hydrazinecarboxylate C11H11N5O7 详情 详情
Extended Information