6,8-dinitro-2H-1,4-benzoxazine-3(4H)-thione -Drug Synthesis Database

【结构式】

【分子编号】27365

【品名】6,8-dinitro-2H-1,4-benzoxazine-3(4H)-thione

【CA登记号】

【分子式】C₈H₅N₃O₅S

【分子量】255.21092

【元素组成】C 37.65% H 1.97% N 16.46% O 31.35% S 12.56%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(I)

The reaction of 6,8-dinitro-2H-1,4-benzoxazine-3(4H)-thione (I) with ethyl carbazate (II) in refluxing ethanol gives 6,8-dinitro-3-(2-ethoxy-carbonyl)hydrazino-2H-1,4-benzoxazine (III), which undergoes ring closure in refluxing o-dichlorobenzene to give the title compound.

参考文献中间体

合成目标

【1】 Shridhar, D.R.; Potential diuretics. Part I. Synthesis of some substituted 2,4-dihydro-1-oxo/thioxo-1,2,4-triazolo[3,4-c][1,4]benzoxazines - Novel diuretic agents. Indian J Chem 1984, 238, 1279.
【2】 Shridhar, D.R.; Arya, V.P.; IDPH-8032. Drugs Fut 1985, 10, 7, 559.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	27365	6,8-dinitro-2H-1,4-benzoxazine-3(4H)-thione		C₈H₅N₃O₅S	详情	详情
(II)	27366	Ethyl hydrazinecarboxylate; Ethyl 1-hydrazinecarboxylate	4114-31-2	C₃H₈N₂O₂	详情	详情
(III)	27367	ethyl 2-(6,8-dinitro-2H-1,4-benzoxazin-3-yl)-1-hydrazinecarboxylate		C₁₁H₁₁N₅O₇	详情	详情

Extended Information