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【结 构 式】

【分子编号】27363

【品名】N-(2-aminoethyl)-5-isoquinolinesulfonamide

【CA登记号】

【 分 子 式 】C11H13N3O2S

【 分 子 量 】251.30924

【元素组成】C 52.57% H 5.21% N 16.72% O 12.73% S 12.76%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(III)

The reaction of 5-isoquinolinesulfonyl chloride (I) with ethyldiamine (II) in methylene chloride gives N-(2-aminoethyl)isoquinoline-5-sulfonamide (III), which is then condensed with S-methylisothiourea sulfate (IV) by means of NaOH at 80 C.

1 Asano, T.; Hidaka, H.; Vasodilatory action of HA-1004 [N-(2-guanidinoethyl)-5-isoquinolinesulfonamide], a novel calcium antagonist with no efect on cardiac function. J Pharmacol Exp Ther 1984, 231, 1, 141.
2 Koch, H.; Castaner, J.; HA-1004. Drugs Fut 1985, 10, 10, 815.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 27362 5-isoquinolinesulfonyl chloride 84468-15-5 C9H6ClNO2S 详情 详情
(II) 14754 ethylenediamine;1,2-Diaminoethane;ethane-1,2-diamine;1,2-Ethanediamine 107-15-3 C2H8N2 详情 详情
(III) 27363 N-(2-aminoethyl)-5-isoquinolinesulfonamide C11H13N3O2S 详情 详情
(IV) 10272 [[Amino(imino)methyl]sulfanyl]methane 2986-19-8 C2H6N2S 详情 详情
Extended Information