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【结 构 式】 
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【分子编号】27298 【品名】4-[(E)-2-(3-acetyl-2-hydroxyphenyl)ethenyl]phenyl acetate 【CA登记号】 |
【 分 子 式 】C18H16O4 【 分 子 量 】296.32264 【元素组成】C 72.96% H 5.44% O 21.6% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(XVI)In a related synthesis, styrene (XV) was coupled with iodoacetophenone (VI) to afford stilbene (XVI). The benzopyranone system (XVII) was constructed by condensation with diethyl oxalate, followed by acid cyclization. Subsequent alkylation of the phenolic hydroxyl group with 4-phenylbutyl bromide (XVIII) gave the previously described ether (XIII), which was then converted into the target compound using the same reaction sequence as before.
| 【1】 Cabre,M.; Borras, L.; Pascual, J.; et al.; Novel stilbene derivatives as LTD4 antagonists. 15th European Federation for Medicinal Chemistry International Symposium on Medicinal Chemistry (Sept 6 1998, Edinburgh) 1998, Abst P.53. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (XVIIII) | 27300 | 1-(4-bromobutyl)benzene; (4-bromobutyl)benzene | 13633-25-5 | C10H13Br | 详情 | 详情 |
| (VI) | 27290 | 1-(2-hydroxy-3-iodophenyl)-1-ethanone | C8H7IO2 | 详情 | 详情 | |
| (XIII) | 27295 | ethyl 4-oxo-8-[(E)-2-[4-(4-phenylbutoxy)phenyl]ethenyl]-4H-chromene-2-carboxylate | C30H28O5 | 详情 | 详情 | |
| (XIV) | 27296 | 4-oxo-8-[(E)-2-[4-(4-phenylbutoxy)phenyl]ethenyl]-4H-chromene-2-carbonitrile | C28H23NO3 | 详情 | 详情 | |
| (XV) | 27297 | 4-vinylphenyl acetate | 2628-16-2 | C10H10O2 | 详情 | 详情 |
| (XVI) | 27298 | 4-[(E)-2-(3-acetyl-2-hydroxyphenyl)ethenyl]phenyl acetate | C18H16O4 | 详情 | 详情 | |
| (XVII) | 27299 | ethyl 8-[(E)-2-(4-hydroxyphenyl)ethenyl]-4-oxo-4H-chromene-2-carboxylate | C20H16O5 | 详情 | 详情 |
Extended Information