(1'R,2'S,5'R)-1',5'-Dihydroxy-2'-(hydroxymethyl)-2',5',7'-trimethyl-2',4',5',6'-tetrahydro-1'H-spiro[cyclopropane-1,6'-inden]-4'-one -Drug Synthesis Database

【结构式】

【分子编号】27127

【品名】(1'R,2'S,5'R)-1',5'-Dihydroxy-2'-(hydroxymethyl)-2',5',7'-trimethyl-2',4',5',6'-tetrahydro-1'H-spiro[cyclopropane-1,6'-inden]-4'-one

【CA登记号】

【分子式】C₁₅H₂₀O₄

【分子量】264.3214

【元素组成】C 68.16% H 7.63% O 24.21%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(XIII)

(R)-Compound.- The treatment of illudin S (XIII) with sulfuric acid gives the tricyclic ketone (XII) as a single (R)-enantiomer (R)-(XII), which is hydroxymethylated with formaldehyde and sulfuric acid as before to provide the (R)-enantiomer of the target compound.

参考文献中间体

合成目标

【1】 Brummond, K.M.; Lu, J.; A short synthesis of the potent antitumor agent (±)-hydroxymethylacylfulvene using allenic pauson-khand type cycloaddition. J Am Chem Soc 1999, 121, 21, 5087.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(R)-(XII)	26689	6(R)-6-Hydroxy-2,4,6-trimethyl-6,7-dihydro-5H-spiro[indene-5,1'-cyclopropan]-7-one; 6(R)-6-Hydroxy-2,4,6-trimethyl-6,7-dihydro-5H-spiro[indene-5,1'-cyclopropan]-7-one		C₁₄H₁₆O₂	详情	详情
(XIII)	27127	(1'R,2'S,5'R)-1',5'-Dihydroxy-2'-(hydroxymethyl)-2',5',7'-trimethyl-2',4',5',6'-tetrahydro-1'H-spiro[cyclopropane-1,6'-inden]-4'-one		C₁₅H₂₀O₄	详情	详情

Extended Information