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【结 构 式】 
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【分子编号】27094 【品名】tert-butyl (5S)-6-([(1S)-2-[[(1S)-1-(aminocarbonyl)-3-methylbutyl]amino]-1-[4-(tert-butoxy)benzyl]-2-oxoethyl]amino)-5-[[(2S)-6-[(tert-butoxycarbonyl)amino]-2-(stearoylamino)hexanoyl]amino]-6-oxohexylcarbamate 【CA登记号】 |
【 分 子 式 】C59H105N7O10 【 分 子 量 】1072.52388 【元素组成】C 66.07% H 9.87% N 9.14% O 14.92% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(VIII)Peptide resin (VII) was then coupled with stearic acid to yield (VIII). Finally, the target peptide amide was deprotected and cleaved from the resin by means of a mixture of trifluoroacetic acid, water and triethylsilane.
| 【1】 Davidson, A.; Fridkin, M.; Perl, O.; Rubinraut, S.; Gozes, I.; Ashur-Fabian, O.; Giladi, E.; Mapping the active site in vasoactive intestinal to a core of four amino acids: Neuroprotective drug design. Proc Natl Acad Sci USA 1999, 96, 7, 4143. |
| 【2】 Gozes, I.; Fridkin, M. (Yeda Research & Development Co. Ltd.); Conjugates of lipophilic moieties and fragments of vasoactive intestinal peptide (VIP). WO 9740070 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (A) | 27095 | stearic acid | 57-11-4 | C18H36O2 | 详情 | 详情 |
| (VI) | 27092 | tert-butyl (5S)-5-amino-6-([(1S)-2-[[(1S)-1-(aminocarbonyl)-3-methylbutyl]amino]-1-[4-(tert-butoxy)benzyl]-2-oxoethyl]amino)-6-oxohexylcarbamate | C30H51N5O6 | 详情 | 详情 | |
| (VII) | 27093 | tert-butyl (5S)-5-amino-6-([(1S)-1-[([(1S)-2-[[(1S)-1-(aminocarbonyl)-3-methylbutyl]amino]-1-[4-(tert-butoxy)benzyl]-2-oxoethyl]amino)carbonyl]-5-[(tert-butoxycarbonyl)amino]pentyl]amino)-6-oxohexylcarbamate | C41H71N7O9 | 详情 | 详情 | |
| (VIII) | 27094 | tert-butyl (5S)-6-([(1S)-2-[[(1S)-1-(aminocarbonyl)-3-methylbutyl]amino]-1-[4-(tert-butoxy)benzyl]-2-oxoethyl]amino)-5-[[(2S)-6-[(tert-butoxycarbonyl)amino]-2-(stearoylamino)hexanoyl]amino]-6-oxohexylcarbamate | C59H105N7O10 | 详情 | 详情 |
Extended Information