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【结 构 式】

【分子编号】27094

【品名】tert-butyl (5S)-6-([(1S)-2-[[(1S)-1-(aminocarbonyl)-3-methylbutyl]amino]-1-[4-(tert-butoxy)benzyl]-2-oxoethyl]amino)-5-[[(2S)-6-[(tert-butoxycarbonyl)amino]-2-(stearoylamino)hexanoyl]amino]-6-oxohexylcarbamate

【CA登记号】

【 分 子 式 】C59H105N7O10

【 分 子 量 】1072.52388

【元素组成】C 66.07% H 9.87% N 9.14% O 14.92%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(VIII)

Peptide resin (VII) was then coupled with stearic acid to yield (VIII). Finally, the target peptide amide was deprotected and cleaved from the resin by means of a mixture of trifluoroacetic acid, water and triethylsilane.

1 Davidson, A.; Fridkin, M.; Perl, O.; Rubinraut, S.; Gozes, I.; Ashur-Fabian, O.; Giladi, E.; Mapping the active site in vasoactive intestinal to a core of four amino acids: Neuroprotective drug design. Proc Natl Acad Sci USA 1999, 96, 7, 4143.
2 Gozes, I.; Fridkin, M. (Yeda Research & Development Co. Ltd.); Conjugates of lipophilic moieties and fragments of vasoactive intestinal peptide (VIP). WO 9740070 .
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(A) 27095 stearic acid 57-11-4 C18H36O2 详情 详情
(VI) 27092 tert-butyl (5S)-5-amino-6-([(1S)-2-[[(1S)-1-(aminocarbonyl)-3-methylbutyl]amino]-1-[4-(tert-butoxy)benzyl]-2-oxoethyl]amino)-6-oxohexylcarbamate C30H51N5O6 详情 详情
(VII) 27093 tert-butyl (5S)-5-amino-6-([(1S)-1-[([(1S)-2-[[(1S)-1-(aminocarbonyl)-3-methylbutyl]amino]-1-[4-(tert-butoxy)benzyl]-2-oxoethyl]amino)carbonyl]-5-[(tert-butoxycarbonyl)amino]pentyl]amino)-6-oxohexylcarbamate C41H71N7O9 详情 详情
(VIII) 27094 tert-butyl (5S)-6-([(1S)-2-[[(1S)-1-(aminocarbonyl)-3-methylbutyl]amino]-1-[4-(tert-butoxy)benzyl]-2-oxoethyl]amino)-5-[[(2S)-6-[(tert-butoxycarbonyl)amino]-2-(stearoylamino)hexanoyl]amino]-6-oxohexylcarbamate C59H105N7O10 详情 详情
Extended Information