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【结 构 式】 
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【分子编号】27090 【品名】1H-imidazol-1-yl[8-(2-methoxyethoxy)-2-phenyl-4-quinolinyl]methanone 【CA登记号】 |
【 分 子 式 】C22H19N3O3 【 分 子 量 】373.41128 【元素组成】C 70.76% H 5.13% N 11.25% O 12.85% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(V)Quinoline (IV) was prepared by condensation of 2-(2-methoxyethyl)aniline (I), pyruvic acid (II) and benzaldehyde (III) in refluxing EtOH. After activation of (IV) as the imidazolide (V) by means of 1,1'-carbonyldiimidazole in DMF, its condensation with guanidine (VI) in the same solvent yielded the corresponding acyl guanidine.
| 【1】 Doebner, O.; Ueber alpha-alkylcinchoninsauren. Ber 1887, 20, 277-80. |
| 【2】 Pfitzinger, W.; Chinolinederivate aus isatinsaure. J Prakt Chem 1886, 33, 100. |
| 【3】 Kitamori, T.; Hosoya, J.; Mori, H.; Banno, H.; Kibayashi, K.; Yamashita, H.; Fujiwara, J.; MS-31-038. Drugs Fut 1999, 24, 12, 1306. |
| 【4】 Fujiwara, J.; Mori, H.; Yamashita, H.; Kitamori, T.; Hosoya, J.; Banno, H. (Mitsui Chemicals, Inc.); Quinoline-4-carbonylguanidine derivates, process for producing the same and pharmaceutical compsns. containing the cpds.. EP 0726254; JP 1996277269; US 5627193 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 27088 | 2-(2-methoxyethoxy)aniline | C9H13NO2 | 详情 | 详情 | |
| (II) | 24066 | 2-oxopropionic acid | 127-17-3 | C3H4O3 | 详情 | 详情 |
| (III) | 10498 | Benzaldehyde;Benzoic aldehyde;Phenylmethanal | 100-52-7 | C7H6O | 详情 | 详情 |
| (IV) | 27089 | 8-(2-methoxyethoxy)-2-phenyl-4-quinolinecarboxylic acid | C19H17NO4 | 详情 | 详情 | |
| (V) | 27090 | 1H-imidazol-1-yl[8-(2-methoxyethoxy)-2-phenyl-4-quinolinyl]methanone | C22H19N3O3 | 详情 | 详情 | |
| (VI) | 14790 | Guanidine | 113-00-8 | CH5N3 | 详情 | 详情 |
Extended Information