5-methyl-1H-indazole -Drug Synthesis Database

【结构式】

【分子编号】27050

【品名】5-methyl-1H-indazole

【CA登记号】

【分子式】C₈H₈N₂

【分子量】132.165

【元素组成】C 72.7% H 6.1% N 21.2%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(V)

The radical bromination of 5-methylidazole (V) by means of N-bromosuccinimide (NBS) and benzoyl peroxide in refluxing CCl4 gives the corresponding bromomethyl derivative (VI), which is then condensed with the diazepine (IV) as before.

参考文献中间体

合成目标

【1】 Wang, H.; Johnson, B.L.; Rodgers, J.D.; et al.; Potent cyclic urea HIV protease inhibitors with benzofused heterocycles as P2/P2' groups. Bioorg Med Chem Lett 1996, 6, 24, 2919.

中间体序号	中间体编号	品名	分子式	供应商	用于合成
(IV)	27049	(3aS,4R,8R,8aS)-4,8-dibenzyl-2,2-dimethylhexahydro-6H-[1,3]dioxolo[4,5-e][1,3]diazepin-6-one	C₂₂H₂₆N₂O₃	详情	详情
(V)	27050	5-methyl-1H-indazole	C₈H₈N₂	详情	详情
(VI)	27051	5-(bromomethyl)-1H-indazole	C₈H₇BrN₂	详情	详情

Extended Information