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【结 构 式】 
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【分子编号】27047 【品名】1H-indazol-5-ylmethanol 【CA登记号】 |
【 分 子 式 】C8H8N2O 【 分 子 量 】148.1644 【元素组成】C 64.85% H 5.44% N 18.91% O 10.8% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(II)The reduction of indazole-5-carboxylic acid (I) with diisobutylaluminum hydride (DIBAL) in dichloromethane gives the expected methanol (II), which by reaction with mesyl chloride and ethyldiisopropylamine in DMF is converted into 5-(chloromethyl)indazole (III). Finally, this compound is condensed with (4R,5S,6S,7R)-4,7-dibenzyl-5,6-dihydroxyperhydro-1,3-diazepin-2-one (IV) by means of NaH in DMF.
| 【1】 Wang, H.; Johnson, B.L.; Rodgers, J.D.; et al.; Potent cyclic urea HIV protease inhibitors with benzofused heterocycles as P2/P2' groups. Bioorg Med Chem Lett 1996, 6, 24, 2919. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 27046 | 1H-indazole-5-carboxylic acid | C8H6N2O2 | 详情 | 详情 | |
| (II) | 27047 | 1H-indazol-5-ylmethanol | C8H8N2O | 详情 | 详情 | |
| (III) | 27048 | 5-(chloromethyl)-1H-indazole | C8H7ClN2 | 详情 | 详情 | |
| (IV) | 27049 | (3aS,4R,8R,8aS)-4,8-dibenzyl-2,2-dimethylhexahydro-6H-[1,3]dioxolo[4,5-e][1,3]diazepin-6-one | C22H26N2O3 | 详情 | 详情 |
Extended Information