|
【结 构 式】 
|
【分子编号】27037 【品名】(2R,6S,9S,11R,12R,14aS,15S,16S,20S,23S,25aS)-9-Amino-23-[(1S,2S)-2-[4-(dibenzylphosphoryloxy)phenyl]-1,2-dihydroxyethyl]-2,11,12,15-tetrahydroxy-6,20-bis(1(R)-hydroxyethyl)-.16-methyloctadecahydro-1H-dipyrrolo[2,1-c:2,1-l][1,4,7,10,13,16]hexaazacyclohenicosine-5,8,14,19,22,25-hexaone 【CA登记号】 |
【 分 子 式 】C48H64N7O18P 【 分 子 量 】1058.046302 【元素组成】C 54.49% H 6.1% N 9.27% O 27.22% P 2.93% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(III)The synthesis of LY-307853 (the phosphate prodrug of LY-303366) has been performed: The phosphorylation of LY-303366 (I) with tetrabenzyl pyrophosphate (II) by means of LiOH in DMF gives dibenzyl phosphate (III), which is finally debenzylated by hydrogenation with H2 over Pd/C in the presence of sodium acetate.
| 【1】 Udodong, U.E.; et al.; Studies on the phosphorylation of LY303366. Tetrahedron Lett 1998, 39, 34, 6115. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 16118 | (2R,6S,9S,11R,12R,14aS,15S,16S,20S,23S,25aS)-9-amino-23-[(1S,2S)-1,2-dihydroxy-2-(4-hydroxyphenyl)ethyl]-2,11,12,15-tetrahydroxy-6,20-bis[(1R)-1-hydroxyethyl]-16-methylhexadecahydro-1H-dipyrrolo[2,1-c:2,1-l][1,4,7,10,13,16]hexaazacyclohenicosine-5,8,14,19,22,25(9H,25aH)-hexone | C34H51N7O15 | 详情 | 详情 | |
| (II) | 27036 | Tetrabenzyl diphosphate; Tetrabenzyl pyrophosphate; Pyrophosphoric acid tetrabenzyl ester; 1,1,3,3-tetrakis(benzyloxy)-3-oxo-1lambda(5),3lambda(5)-diphosphoxan-1-one | 990-91-0 | C28H28O7P2 | 详情 | 详情 |
| (III) | 27037 | (2R,6S,9S,11R,12R,14aS,15S,16S,20S,23S,25aS)-9-Amino-23-[(1S,2S)-2-[4-(dibenzylphosphoryloxy)phenyl]-1,2-dihydroxyethyl]-2,11,12,15-tetrahydroxy-6,20-bis(1(R)-hydroxyethyl)-.16-methyloctadecahydro-1H-dipyrrolo[2,1-c:2,1-l][1,4,7,10,13,16]hexaazacyclohenicosine-5,8,14,19,22,25-hexaone | C48H64N7O18P | 详情 | 详情 |
Extended Information