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【结 构 式】

【分子编号】27001

【品名】ethyl 3-[3-(2-aminoethyl)-5-(4-fluorobenzyl)phenyl]propanoate

【CA登记号】

【 分 子 式 】C20H24FNO2

【 分 子 量 】329.4145032

【元素组成】C 72.92% H 7.34% F 5.77% N 4.25% O 9.71%

与该中间体有关的原料药合成路线共 2 条

合成路线1

该中间体在本合成路线中的序号:(XIV)

The reaction of monoacid (VIII) with diphenylphosphoryl azide and triethylamine in refluxing tert-butanol gives the tert-butoxycarbonyl aminoester (XIII), which is deprotected with trifluoroacetic acid to yield the aminoester (XIV). The sulfonation of (XIV) with 4-chlorophenylsulfonyl chloride (XII) and triethylamine in dichloromethane affords the sulfonamido ester (XV), which is finally hydrolyzed with NaOH in refluxing methanol.

1 Dickinson, R.P.; Dack, K.N.; Steele, J. (Pfizer Inc.); Benzenealkanoic acids for cardiovascular diseases. EP 0662950; JP 1996502046; US 5618941; WO 9406761 .
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(VIII) 26996 3-[3-(3-ethoxy-3-oxopropyl)-5-(4-fluorobenzyl)phenyl]propionic acid C21H23FO4 详情 详情
(XII) 15787 4-chlorobenzenesulfonyl chloride;4-chlorobenzene-1-sulfonyl chloride 98-60-2 C6H4Cl2O2S 详情 详情
(XIII) 27000 ethyl 3-[3-[2-[(tert-butoxycarbonyl)amino]ethyl]-5-(4-fluorobenzyl)phenyl]propanoate C25H32FNO4 详情 详情
(XIV) 27001 ethyl 3-[3-(2-aminoethyl)-5-(4-fluorobenzyl)phenyl]propanoate C20H24FNO2 详情 详情
(XV) 27002 ethyl 3-[3-(2-[[(4-chlorophenyl)sulfonyl]amino]ethyl)-5-(4-fluorobenzyl)phenyl]propanoate C26H27ClFNO4S 详情 详情

合成路线2

该中间体在本合成路线中的序号:(XI)

The reaction of 3-bromo-5-iodobenzoic acid (I) with SOCl2 gives the corresponding acyl chloride (II), which by a Friedel-Crafts condensation with fluorobenzene (II) by means of AlCl3 in refluxing dichloromethane yields the benzophenone (IV). The condensation of (IV) with ethyl acrylate (V) by means of palladium acetate and triethylamine in refluxing acetonitrile affords the cinnamic acid derivative (VI), which is condensed with N-vinylphthalimide (VII) by means of palladium acetate and diisopropylamine in refluxing xylene to provide the unsaturated adduct (VIII). The reduction of the carbonyl group of (VIII) with triethylsilane and TFA gives the diphenylmethane derivative (IX), which is hydrogenated with H2 over Pd/C in ethyl acetate to yield the saturated diphenylmethane derivative (X). Elimination of the phthalimido group of (X) with hydrazine affords (XI) with a primary amino group. that is sulfonated with 4-chlorophenylsulfonyl chloride (XII) and triethylamine in THF to provide the sulfonamide (XIII). Finally, the ester group of (XIII) is hydrolyzed with aqueous NaOH.

1 Waite, D.C.; Mason, C.P.; A scalable synthesis of the thromboxane receptor antagonist 3-(3-[2-(4-chlorobenzenesulfonamido)ethyl]-5-(4-fluorobenzyl)phenyl]propionic acid via a regioselective heck cross-coupling strategy. Org Process Res Dev 1998, 2, 2, 116.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 32745 3-bromo-5-iodobenzoic acid 188815-32-9 C7H4BrIO2 详情 详情
(II) 32746 3-bromo-5-iodobenzoyl chloride C7H3BrClIO 详情 详情
(III) 17466 Fluorobenzene 462-06-6 C6H5F 详情 详情
(IV) 32747 (3-bromo-5-iodophenyl)(4-fluorophenyl)methanone C13H7BrFIO 详情 详情
(V) 10164 ethyl acrylate 140-88-5 C5H8O2 详情 详情
(VI) 32748 ethyl (E)-3-[3-bromo-5-(4-fluorobenzoyl)phenyl]-2-propenoate C18H14BrFO3 详情 详情
(VII) 32749 2-vinyl-1H-isoindole-1,3(2H)-dione 3485-84-5 C10H7NO2 详情 详情
(VIII) 32750 ethyl (E)-3-[3-[(E)-2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)ethenyl]-5-(4-fluorobenzoyl)phenyl]-2-propenoate C28H20FNO5 详情 详情
(IX) 32751 ethyl (E)-3-[3-[(E)-2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)ethenyl]-5-(4-fluorobenzyl)phenyl]-2-propenoate C28H22FNO4 详情 详情
(X) 32752 ethyl 3-[3-[2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)ethyl]-5-(4-fluorobenzyl)phenyl]propanoate C28H26FNO4 详情 详情
(XI) 27001 ethyl 3-[3-(2-aminoethyl)-5-(4-fluorobenzyl)phenyl]propanoate C20H24FNO2 详情 详情
(XII) 15787 4-chlorobenzenesulfonyl chloride;4-chlorobenzene-1-sulfonyl chloride 98-60-2 C6H4Cl2O2S 详情 详情
(XIII) 27002 ethyl 3-[3-(2-[[(4-chlorophenyl)sulfonyl]amino]ethyl)-5-(4-fluorobenzyl)phenyl]propanoate C26H27ClFNO4S 详情 详情
Extended Information