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【结 构 式】 
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【分子编号】26915 【品名】1-cyclopentyl-6-(3-ethoxy-4-pyridinyl)-3-ethyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine 【CA登记号】 |
【 分 子 式 】C19H24N6O 【 分 子 量 】352.4394 【元素组成】C 64.75% H 6.86% N 23.85% O 4.54% |
合成路线1
该中间体在本合成路线中的序号：(XIV)Treatment of 4-cyanopyridine N-oxide (X) with phosphorus oxychloride and phosphorus pentachloride under reflux produced a mixture of 2-chloro (XI) and 3-chloropyridines (XII), which were separated by column chromatography. The 3-chloro isomer (XII) was further treated with sodium ethoxide in DMF to produce the ethoxypyridine (XIII). The pyrazolopyrimidine nucleus (XIV) was then obtained by condensation of cyanopyridine (XIII) with aminopyrazole (IX) in the presence of NaH. Finally, diazotization of (XIV) in 50% sulfuric acid converted the aminopyrimidine group into the required pyrimidinone.
| 【1】 Bacon, E.R.; Singh, B.; Lesher, G.Y.; Lesher, L.E. (Sanofi-Synthelabo); 6-Heterocyclyl pyrazolo[3,4-d]pyrimidin-4-ones and compsns. and method of use. US 5294612 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (IX) | 26911 | 5-amino-1-cyclopentyl-3-ethyl-1H-pyrazole-4-carboxamide | C11H18N4O | 详情 | 详情 | |
| (X) | 26912 | 4-cyano-1-pyridiniumolate | 14906-59-3 | C6H4N2O | 详情 | 详情 |
| (XI) | 23940 | 2-Chloro-4-pyridinecarbonitrile; 2-chloroisonicotinonitrile | 33252-30-1 | C6H3ClN2 | 详情 | 详情 |
| (XII) | 26913 | 3-chloroisonicotinonitrile | C6H3ClN2 | 详情 | 详情 | |
| (XIII) | 26914 | 3-ethoxyisonicotinonitrile | C8H8N2O | 详情 | 详情 | |
| (XIV) | 26915 | 1-cyclopentyl-6-(3-ethoxy-4-pyridinyl)-3-ethyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine | C19H24N6O | 详情 | 详情 |