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【结 构 式】 
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【分子编号】26625 【品名】4-[amino(imino)methyl]benzamide 【CA登记号】59855-11-7 |
【 分 子 式 】C8H9N3O 【 分 子 量 】163.17908 【元素组成】C 58.88% H 5.56% N 25.75% O 9.8% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(XV)The intermediate 4-(tert-butoxycarbonylamindino)benzoic acid (XII) has been obtained as follows: Comerciaally available 4-amidinobenzamide (XV) is hydrolyzed with aqueous HCl to give 4-amidinobenzoic acid (XVI), which is then treated with tert-butoxycarbonyl anhydride and N,O-bis(trimethylsilyl)acetamide in dichloromethane to afford the target intermediate (XII).
| 【1】 Ikeda, Y.; Ueki, Y.; Kishimoto, H.; Nishihara, T.; Kamikawa, Y. (Sumitomo Pharmaceuticals Co., Ltd.); 2,3-Diaminopropionic acid deriv.. US 5707994; US 6048854; WO 9511228 . |
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