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【结 构 式】 
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【分子编号】26569 【品名】2-[N,N-Bis[2-[N,N-bis(carboxymethyl)amino]ethyl]amino]-6-[N-(4-pentylbicyclo[2,2,2]oct-1-ylcarbonyl)-L-aspartyl-L-aspartylamino]hexanoic acid; 2-[N,N-Bis[2-[N,N-bis(carboxymethyl)amino]ethyl]amino]-6-[N-(4-pentylbicyclo[2,2,2]oct-1-ylcarbonyl)-L-aspartyl-L-aspartylamino]hexanoic acid 【CA登记号】 |
【 分 子 式 】C40H64N6O17 【 分 子 量 】900.9784 【元素组成】C 53.32% H 7.16% N 9.33% O 30.19% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(VII)After deprotection of the tert-butyl ester groups of (VI) with HCl in dioxan, the resulting heptacarboxylic acid (VII) was treated with gadolinium (III) oxide at a controlled pH value to furnish the target gadolinium chelate.
| 【1】 Wallace, R.A.; Haar, J.P. Jr.; Miller, D.B.; Woulfe, S.R.; Polta, J.A.; Galen, K.P.; Hynes, M.R.; Adzamli, K.; Synthesis and preliminary evaluation of MP-2269: A novel, nonaromatic small-molecule blood-pool MR contrast agent. Magn Reson Med 1998, 40, 5, 733. |
| 【2】 Woulfe, S.R. (Mallinckrodt Medical Inc.); Magnetic resonance blood pool agents. WO 9820908 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (VI) | 26568 | 2-[N,N-Bis[2-[N,N-bis(tert-butoxycarbonylmethyl)amino]ethyl]amino]-6-[N-(4-pentylbicyclo[2,2,2]oct-1-ylcarbonyl)-(4-O-tert-butyl)-L-aspartyl-(4-O-tert-butyl)-L-aspartylamino]hexanoic acid tert-butyl ester; 2-[N,N-Bis[2-[N,N-bis(tert-butoxycarbonylmethyl)amino]ethyl]amino]-6-[N-(4-pentylbicyclo[2,2,2]oct-1-ylcarbonyl)-(4-O-tert-butyl)-L-aspartyl-(4-O-tert-butyl)-L-aspartylamino]hexanoic acid tert-butyl ester | C68H120N6O17 | 详情 | 详情 | |
| (VII) | 26569 | 2-[N,N-Bis[2-[N,N-bis(carboxymethyl)amino]ethyl]amino]-6-[N-(4-pentylbicyclo[2,2,2]oct-1-ylcarbonyl)-L-aspartyl-L-aspartylamino]hexanoic acid; 2-[N,N-Bis[2-[N,N-bis(carboxymethyl)amino]ethyl]amino]-6-[N-(4-pentylbicyclo[2,2,2]oct-1-ylcarbonyl)-L-aspartyl-L-aspartylamino]hexanoic acid | C40H64N6O17 | 详情 | 详情 |
Extended Information