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【结 构 式】 
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【分子编号】26533 【品名】2-bromoethyl 4-amino-5-chloro-2-methoxybenzoate 【CA登记号】 |
【 分 子 式 】C10H11BrClNO3 【 分 子 量 】308.55898 【元素组成】C 38.93% H 3.59% Br 25.9% Cl 11.49% N 4.54% O 15.56% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(II)Reaction of 4-amino-5-chloro-2-methoxybenzoic acid (I) with 1,2-dibromoethane in the presence of 1,8-diazabicyclo[5.4.0]undec-7-ene afforded bromoethyl ester (II). This was then condensed with a mixture of cis and trans 3,5-dimethylpiperidines (III), and the resulting mixture of amines was finally separated by column chromatogaphy to provide the target cis compound.
| 【1】 Sicsic, S.; Soulier, J.-L.; Yang, D.; et al.; New esters of 4-amino-5-chloro-2-methoxybenzoic acid as potent agonists and antagonists for 5-HT4 receptors. J Med Chem 1997, 40, 4, 608. |
| 【2】 Langlois, M.; Guzzi, U.; Cecchi, R.; Croci, T. (Midy SpA); Esters of 4-amino-5-chloro-2-methoxybenzoic acid, process for their preparation and pharmaceutical compsns. containing them. EP 0683161 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| 10252 | 1,2-Dibromoethane; Ethylene dibromide | 106-93-4 | C2H4Br2 | 详情 | 详情 | |
| (I) | 12419 | 4-Amino-5-chloro-2-methoxybenzoic acid | 7206-70-4 | C8H8ClNO3 | 详情 | 详情 |
| (II) | 26533 | 2-bromoethyl 4-amino-5-chloro-2-methoxybenzoate | C10H11BrClNO3 | 详情 | 详情 | |
| (III) | 26534 | 3,5-dimethylpiperidine | 35794-11-7 | C7H15N | 详情 | 详情 |
Extended Information