4-Amino-3(S)-(benzyloxycarbonylamino)-4-oxobutyric acid 2-(isopropoxycarbonyloxy)-2-oxoethyl ester -Drug Synthesis Database

【结构式】

【分子编号】26493

【品名】4-Amino-3(S)-(benzyloxycarbonylamino)-4-oxobutyric acid 2-(isopropoxycarbonyloxy)-2-oxoethyl ester

【CA登记号】

【分子式】C₁₈H₂₂N₂O₉

【分子量】410.38076

【元素组成】C 52.68% H 5.4% N 6.83% O 35.09%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(XXXV)

In an alternative procedure, acid (XXVII) was activated as the mixed anhydride (XXXV) with isopropyl chloroformate (XXXIV), and then condensed with taxane intermediate (XIV) to give ester (XXVI). Hydrogenolytic deprotection of the N-carbobenzoy group of (XXVI) yielded the title compound.

参考文献中间体

合成目标

【1】 Tsujihari, K.; Hashiyama, T.; Ohashi, M.; Nakanishi, N. (Tanabe Seiyaku Co., Ltd.); Baccatin derivs. and processes for preparing the same. CA 2162759; EP 0712854; JP 1997151181; US 5589502 .

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(XIV)	26474	methyl (9S,12S)-4-methoxy-12-[[(2S,5S,8S,11R)-5-(4-methoxybenzyl)-2,6,8,11,15,15-hexamethyl-4,7,10,13-tetraoxo-14-oxa-3,6,9,12-tetraazahexadec-1-anoyl](methyl)amino]-11-oxo-2-oxa-10-azatricyclo[12.2.2.1(3,7)]nonadeca-1(16),3(19),4,6,14,17-hexaene-9-carboxylate		C₄₀H₅₃NO₁₄	详情	详情
(XXVI)	26484	(1S,2S,3R,4S,7R,9S,10S,12R,15S)-4-(acetoxy)-2-(benzoyloxy)-1,9,12-trihydroxy-10,14,17,17-tetramethyl-11-oxo-6-oxatetracyclo[11.3.1.0(3,10).0(4,7)]heptadec-13-en-15-yl (5S,12R)-5-(aminocarbonyl)-12-[(S)-[(tert-butoxycarbonyl)amino](cyclopropyl)methyl]-3,7,10-trioxo-1-phenyl-2,8,11-trioxa-4-azatridecan-13-oate		C₅₄H₆₇N₃O₂₀	详情	详情
(XXVII)	26485	1-(dimethoxymethyl)-4-methoxybenzene	2186-92-7	C₁₀H₁₄O₃	详情	详情
(XXXIV)	26492	2-[(chlorocarbonyl)oxy]propane	108-23-6	C₄H₇ClO₂	详情	详情
(XXXV)	26493	4-Amino-3(S)-(benzyloxycarbonylamino)-4-oxobutyric acid 2-(isopropoxycarbonyloxy)-2-oxoethyl ester		C₁₈H₂₂N₂O₉	详情	详情

Extended Information