tert-butyl [(tert-butoxycarbonyl)imino](methylsulfanyl)methyl(3-methyl-2-butenyl)carbamate -Drug Synthesis Database

【结构式】

【分子编号】26452

【品名】tert-butyl [(tert-butoxycarbonyl)imino](methylsulfanyl)methyl(3-methyl-2-butenyl)carbamate

【CA登记号】

【分子式】C₁₇H₃₀N₂O₄S

【分子量】358.50228

【元素组成】C 56.96% H 8.43% N 7.81% O 17.85% S 8.94%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(II)

The condensation of 3,4-dimethoxy-N-(4-aminobutyl)cinnamamide (I) with N,N'-bis(tert-butoxycarbonyl)-S-methyl-N-(3-methyl-2-butenyl)isothiourea (II) gives the protected target compound (III), which is finally deprotected by treatment with methanesulfonic acid.

参考文献中间体

合成目标

【1】 Delle Monache, G.; et al.; Caracasanamide, a novel hypotensive agent from verbesina caracasana. Bioorg Med Chem Lett 1992, 2, 5, 415.

中间体序号	中间体编号	品名	分子式	供应商	用于合成
(I)	26451	(E)-N-(4-aminobutyl)-3-(3,4-dimethoxyphenyl)-2-propenamide	C₁₅H₂₂N₂O₃	详情	详情
(II)	26452	tert-butyl [(tert-butoxycarbonyl)imino](methylsulfanyl)methyl(3-methyl-2-butenyl)carbamate	C₁₇H₃₀N₂O₄S	详情	详情
(III)	26453	tert-butyl [(tert-butoxycarbonyl)imino][(4-[[(E)-3-(3,4-dimethoxyphenyl)-2-propenoyl]amino]butyl)amino]methyl(3-methyl-2-butenyl)carbamate	C₃₁H₄₈N₄O₇	详情	详情

Extended Information