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【结 构 式】 
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【分子编号】26361 【品名】methyl (E)-2-butenoate 【CA登记号】623-43-8 |
【 分 子 式 】C5H8O2 【 分 子 量 】100.11732 【元素组成】C 59.98% H 8.05% O 31.96% |
合成路线1
该中间体在本合成路线中的序号：(V)Raxofelast has been synthesized by a short route involving Friedel-Crafts alkylation of trimethylhydroquinone (I) by methyl 4-bromocrotonate (II). The crude reaction mixture containing methyl 4-(2,5-dihydroxy-3,4,6-trimethylphenyl)-2(E)-butenoate (III) was directly submitted to a hydrolytic cyclization in alkaline environment in the presence of a strong reducing agent to afford (±)-2,3-dihydro-5-hydroxy-4,6,7-trimethyl-2-benzofuranacetic acid (IV) (IRFI-005). Acetylation of phenolic hydroxyl by routine methods, followed by recrystallization by isopropyl acetate, gave the final product.
| 【1】 De Vellis, P.; Scuri, R.; Zanarella, S.; Ceccarelli, S.; Synthesis of novel 2-substituted 5-oxycoumarans via a direct route to 2,3-dihydro-5-hydroxy-2-benzofuranacetic acids. J Heterocycl Chem 1993, 30, 679. |
| 【2】 Cuzzocrea, S.; Ceccarelli, S.; Raxofelast. Drugs Fut 1999, 24, 7, 735. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 26357 | 2,3,5-trimethyl-1,4-benzenediol | 700-13-0 | C9H12O2 | 详情 | 详情 |
| (II) | 26358 | methyl (E)-4-bromo-2-butenoate | 1117-71-1 | C5H7BrO2 | 详情 | 详情 |
| (III) | 26359 | methyl (E)-4-(2,5-dihydroxy-3,4,6-trimethylphenyl)-2-butenoate | C14H18O4 | 详情 | 详情 | |
| (IV) | 26360 | 2-(5-hydroxy-4,6,7-trimethyl-2,3-dihydro-1-benzofuran-2-yl)acetic acid | C13H16O4 | 详情 | 详情 | |
| (V) | 26361 | methyl (E)-2-butenoate | 623-43-8 | C5H8O2 | 详情 | 详情 |
合成路线2
该中间体在本合成路线中的序号：(XIII)The intermediate naphthaleneboronic acid (XIX) has been obtained as follows: The bromination of the 3-methylphenyl methoxymethyl ether (X) with NBS gives the dibromo compound (XI), which is treated with sodium phenylsulfinate to afford the sulfone (XII). The condensation of (XII) with methyl crotonate (XIII) by means of LDA and KOH gives the butyric acid (XIV), which is cyclized to the tetralone (XV) by means of trifluoroacetic anhydride (TFAA). The aromatization of (XV) by means of t-BuOK or NaOH yields the 5-bromo-8-(methoxymethoxy)-3-methyl-1-naphthol (XVI), which is methylated with dimethyl sulfate to afford the methyl ether (XVII). The reaction of (XVII) with trimethyl borate and n-BuLi gives the boronic ester (XVIII), which is hydrolyzed with water and ammonium chloride yielding the desired naphthaleneboronic acid (XIX). Alternatively, the naphthaleneboronic acid (XIX) has been obtained as follows: The reaction of 2,4-dibromophenol methoxymethyl ether (XX) with n-BuLi and cyclohexyl(isopropyl)amine gives the benzyne intermediate (XXI), which, without isolation is cyclized with the lithium enolate of 3-methylcrotonic acid dimethylamide (XXII) to afford the previously described naphthol (XVI), which is purified by chromatography.
| 【1】 Hoye, T.R.; et al.; Total synthesis of michellamines A-C, korupensamines A-D, and ancistrobrevine B. J Org Chem 1999, 64, 19, 7184. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (X) | 37848 | 1-(methoxymethoxy)-3-methylbenzene; methoxymethyl 3-methylphenyl ether | C9H12O2 | 详情 | 详情 | |
| (XI) | 37849 | [4-bromo-3-(bromomethyl)phenoxy]methyl methyl ether; 1-bromo-2-(bromomethyl)-4-(methoxymethoxy)benzene | C9H10Br2O2 | 详情 | 详情 | |
| (XII) | 37850 | 2-bromo-5-(methoxymethoxy)benzyl phenyl sulfone; [2-bromo-5-(methoxymethoxy)benzyl](dioxo)phenyl-lambda(6)-sulfane | C15H15BrO4S | 详情 | 详情 | |
| (XIII) | 26361 | methyl (E)-2-butenoate | 623-43-8 | C5H8O2 | 详情 | 详情 |
| (XIV) | 37851 | 4-[2-bromo-5-(methoxymethoxy)phenyl]-3-methyl-4-(phenylsulfonyl)butyric acid | C19H21BrO6S | 详情 | 详情 | |
| (XV) | 37852 | 5-bromo-8-(methoxymethoxy)-3-methyl-4-(phenylsulfonyl)-3,4-dihydro-1(2H)-naphthalenone | C19H19BrO5S | 详情 | 详情 | |
| (XVI) | 37853 | 5-bromo-8-(methoxymethoxy)-3-methyl-1-naphthol | C13H13BrO3 | 详情 | 详情 | |
| (XVII) | 37854 | 5-bromo-8-(methoxymethoxy)-3-methyl-1-naphthyl methyl ether; 5-bromo-1-methoxy-8-(methoxymethoxy)-3-methylnaphthalene | C14H15BrO3 | 详情 | 详情 | |
| (XVIII) | 37855 | dimethyl 5-methoxy-4-(methoxymethoxy)-7-methyl-1-naphthylboronate | C16H21BO5 | 详情 | 详情 | |
| (XIX) | 37856 | 5-methoxy-4-(methoxymethoxy)-7-methyl-1-naphthylboronic acid | C14H17BO5 | 详情 | 详情 | |
| (XX) | 37857 | (2,4-dibromophenoxy)methyl methyl ether; 2,4-dibromo-1-(methoxymethoxy)benzene | C8H8Br2O2 | 详情 | 详情 | |
| (XXI) | 37858 | 1-bromo-4-(methoxymethoxy)-1,3-cyclohexadien-5-yne; 4-bromo-1,3-cyclohexadien-5-yn-1-yl methoxymethyl ether | C8H7BrO2 | 详情 | 详情 | |
| (XXII) | 37859 | C8H14LiNO | 详情 | 详情 |
合成路线3
该中间体在本合成路线中的序号：(XIII)The intermediate naphthaleneboronic acid (XIX) has been obtained as follows: The bromination of the 3-methylphenyl methoxymethyl ether (X) with NBS gives the dibromo compound (XI), which is treated with sodium phenylsulfinate to afford the sulfone (XII). The condensation of (XII) with methyl crotonate (XIII) by means of LDA and KOH gives the butyric acid (XIV), which is cyclized to the tetralone (XV) by means of trifluoroacetic anhydride (TFAA). The aromatization of (XV) by means of t-BuOK or NaOH yields the 5-bromo-8-(methoxymethoxy)-3-methyl-1-naphthol (XVI), which is methylated with dimethylsulfate to afford the methyl ether (XVII). The reaction of (XVII) with trimethyl borate and n-BuLi gives the boronic ester (XVIII), which is hydrolyzed with water and ammonium chloride yielding the desired naphthaleneboronic acid (XIX). Alternatively, the naphthaleneboronic acid (XIX) has been obtained as follows: The reaction of 2,4-dibromophenol methoxymethyl ether (XX) with n-BuLi and cyclohexyl(isopropyl)amine gives the benzyne intermediate (XXI), which, without isolation is cyclized with the lithium enolate of 3-methylcrotonic acid dimethylamide (XXII) to afford the previously described naphthol (XVI), which is purified by chromatography.
| 【1】 Hoye, T.R.; et al.; Total synthesis of michellamines A-C, korupensamines A-D, and ancistrobrevine B. J Org Chem 1999, 64, 19, 7184. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (X) | 37848 | 1-(methoxymethoxy)-3-methylbenzene; methoxymethyl 3-methylphenyl ether | C9H12O2 | 详情 | 详情 | |
| (XI) | 37849 | [4-bromo-3-(bromomethyl)phenoxy]methyl methyl ether; 1-bromo-2-(bromomethyl)-4-(methoxymethoxy)benzene | C9H10Br2O2 | 详情 | 详情 | |
| (XII) | 37850 | 2-bromo-5-(methoxymethoxy)benzyl phenyl sulfone; [2-bromo-5-(methoxymethoxy)benzyl](dioxo)phenyl-lambda(6)-sulfane | C15H15BrO4S | 详情 | 详情 | |
| (XIII) | 26361 | methyl (E)-2-butenoate | 623-43-8 | C5H8O2 | 详情 | 详情 |
| (XIV) | 37851 | 4-[2-bromo-5-(methoxymethoxy)phenyl]-3-methyl-4-(phenylsulfonyl)butyric acid | C19H21BrO6S | 详情 | 详情 | |
| (XV) | 37852 | 5-bromo-8-(methoxymethoxy)-3-methyl-4-(phenylsulfonyl)-3,4-dihydro-1(2H)-naphthalenone | C19H19BrO5S | 详情 | 详情 | |
| (XVI) | 37853 | 5-bromo-8-(methoxymethoxy)-3-methyl-1-naphthol | C13H13BrO3 | 详情 | 详情 | |
| (XVII) | 37854 | 5-bromo-8-(methoxymethoxy)-3-methyl-1-naphthyl methyl ether; 5-bromo-1-methoxy-8-(methoxymethoxy)-3-methylnaphthalene | C14H15BrO3 | 详情 | 详情 | |
| (XVIII) | 37855 | dimethyl 5-methoxy-4-(methoxymethoxy)-7-methyl-1-naphthylboronate | C16H21BO5 | 详情 | 详情 | |
| (XIX) | 37856 | 5-methoxy-4-(methoxymethoxy)-7-methyl-1-naphthylboronic acid | C14H17BO5 | 详情 | 详情 | |
| (XX) | 37857 | (2,4-dibromophenoxy)methyl methyl ether; 2,4-dibromo-1-(methoxymethoxy)benzene | C8H8Br2O2 | 详情 | 详情 | |
| (XXI) | 37858 | 1-bromo-4-(methoxymethoxy)-1,3-cyclohexadien-5-yne; 4-bromo-1,3-cyclohexadien-5-yn-1-yl methoxymethyl ether | C8H7BrO2 | 详情 | 详情 | |
| (XXII) | 37859 | C8H14LiNO | 详情 | 详情 |
合成路线4
该中间体在本合成路线中的序号：(XIII)The intermediate naphthaleneboronic acid (XIX) has been obtained as follows: The bromination of the 3-methylphenyl methoxymethyl ether (X) with NBS gives the dibromo compound (XI), which is treated with sodium phenylsulfinate to afford the sulfone (XII). The condensation of (XII) with methyl crotonate (XIII) by means of LDA and KOH gives the butyric acid (XIV), which is cyclized to the tetralone (XV) by means of trifluoroacetic anhydride (TFAA). The aromatization of (XV) by means of t-BuOK or NaOH yields the 5-bromo-8-(methoxymethoxy)-3-methyl-1-naphthol (XVI), which is methylated with dimethylsulfate to afford the methyl ether (XVII). The reaction of (XVII) with trimethyl borate and n-BuLi gives the boronic ester (XVIII), which is hydrolyzed with water and ammonium chloride yielding the desired naphthaleneboronic acid (XIX). Alternatively, the naphthaleneboronic acid (XIX) has been obtained as follows: The reaction of 2,4-dibromophenol methoxymethyl ether (XX) with n-BuLi and cyclohexyl(isopropyl)amine gives the benzyne intermediate (XXI), which, without isolation is cyclized with the lithium enolate of 3-methylcrotonic acid dimethylamide (XXII) to afford the previously described naphthol (XVI), which is purified by chromatography.
| 【1】 Hoye, T.R.; et al.; Total synthesis of michellamines A-C, korupensamines A-D, and ancistrobrevine B. J Org Chem 1999, 64, 19, 7184. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (X) | 37848 | 1-(methoxymethoxy)-3-methylbenzene; methoxymethyl 3-methylphenyl ether | C9H12O2 | 详情 | 详情 | |
| (XI) | 37849 | [4-bromo-3-(bromomethyl)phenoxy]methyl methyl ether; 1-bromo-2-(bromomethyl)-4-(methoxymethoxy)benzene | C9H10Br2O2 | 详情 | 详情 | |
| (XII) | 37850 | 2-bromo-5-(methoxymethoxy)benzyl phenyl sulfone; [2-bromo-5-(methoxymethoxy)benzyl](dioxo)phenyl-lambda(6)-sulfane | C15H15BrO4S | 详情 | 详情 | |
| (XIII) | 26361 | methyl (E)-2-butenoate | 623-43-8 | C5H8O2 | 详情 | 详情 |
| (XIV) | 37851 | 4-[2-bromo-5-(methoxymethoxy)phenyl]-3-methyl-4-(phenylsulfonyl)butyric acid | C19H21BrO6S | 详情 | 详情 | |
| (XV) | 37852 | 5-bromo-8-(methoxymethoxy)-3-methyl-4-(phenylsulfonyl)-3,4-dihydro-1(2H)-naphthalenone | C19H19BrO5S | 详情 | 详情 | |
| (XVI) | 37853 | 5-bromo-8-(methoxymethoxy)-3-methyl-1-naphthol | C13H13BrO3 | 详情 | 详情 | |
| (XVII) | 37854 | 5-bromo-8-(methoxymethoxy)-3-methyl-1-naphthyl methyl ether; 5-bromo-1-methoxy-8-(methoxymethoxy)-3-methylnaphthalene | C14H15BrO3 | 详情 | 详情 | |
| (XVIII) | 37855 | dimethyl 5-methoxy-4-(methoxymethoxy)-7-methyl-1-naphthylboronate | C16H21BO5 | 详情 | 详情 | |
| (XIX) | 37856 | 5-methoxy-4-(methoxymethoxy)-7-methyl-1-naphthylboronic acid | C14H17BO5 | 详情 | 详情 | |
| (XX) | 37857 | (2,4-dibromophenoxy)methyl methyl ether; 2,4-dibromo-1-(methoxymethoxy)benzene | C8H8Br2O2 | 详情 | 详情 | |
| (XXI) | 37858 | 1-bromo-4-(methoxymethoxy)-1,3-cyclohexadien-5-yne; 4-bromo-1,3-cyclohexadien-5-yn-1-yl methoxymethyl ether | C8H7BrO2 | 详情 | 详情 | |
| (XXII) | 37859 | C8H14LiNO | 详情 | 详情 |
合成路线5
该中间体在本合成路线中的序号：(XIII)The intermediate naphthaleneboronic acid (XIX) has been obtained as follows: The bromination of the 3-methylanisole (X) with NBS gives the dibromo compound (XI), which is treated with sodium phenylsulfinate to afford the sulfone (XII). The condensation of (XII) with methyl crotonate (XIII) by means of LDA and KOH gives the butyric acid (XIV), which is cyclized to the tetralone (XV) by means of trifluoroacetic anhydride (TFAA). The aromatization of (XV) by means of t-BuOK or NaOH yields the 5-bromo-8-methoxy-3-methyl-1-naphthol (XVI), which is methylated with dimethyl sulfate to afford the bis(methyl) ether (XVII). The reaction of (XVII) with trimethyl borate and n-BuLi gives the boronic ester (XVIII), which is hydrolyzed with water and ammonium chloride yielding the desired naphthaleneboronic acid (XIX). Alternatively, the naphthaleneboronic acid (XIX) has been obtained as follows: The reaction of 2,4-dibromoanisole (XX) with n-BuLi and cyclohexyl(isopropyl)amine gives the benzyne intermediate (XXI), which, without isolation is cyclized with the lithium enolate of 3-methylcrotonic acid dimethylamide (XXII) to afford the previously described naphthol (XVI), which is purified by chromatography.
| 【1】 Hoye, T.R.; et al.; Total synthesis of michellamines A-C, korupensamines A-D, and ancistrobrevine B. J Org Chem 1999, 64, 19, 7184. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (X) | 38309 | 1-methoxy-3-methylbenzene; methyl 3-methylphenyl ether | 100-84-5 | C8H10O | 详情 | 详情 |
| (XI) | 27552 | 1-bromo-2-(bromomethyl)-4-methoxybenzene | C8H8Br2O | 详情 | 详情 | |
| (XII) | 38310 | (2-bromo-5-methoxybenzyl)(dioxo)phenyl-lambda(6)-sulfane; 2-bromo-5-methoxybenzyl phenyl sulfone | C14H13BrO3S | 详情 | 详情 | |
| (XIII) | 26361 | methyl (E)-2-butenoate | 623-43-8 | C5H8O2 | 详情 | 详情 |
| (XIV) | 38311 | 4-(2-bromo-5-methoxyphenyl)-3-methyl-4-(phenylsulfonyl)butyric acid | C18H19BrO5S | 详情 | 详情 | |
| (XV) | 38312 | 5-bromo-8-methoxy-3-methyl-4-(phenylsulfonyl)-3,4-dihydro-1(2H)-naphthalenone | C18H17BrO4S | 详情 | 详情 | |
| (XVI) | 38313 | 5-bromo-8-methoxy-3-methyl-1-naphthol | C12H11BrO2 | 详情 | 详情 | |
| (XVII) | 38314 | 5-bromo-1,8-dimethoxy-3-methylnaphthalene; 4-bromo-8-methoxy-6-methyl-1-naphthyl methyl ether | C13H13BrO2 | 详情 | 详情 | |
| (XVIII) | 38315 | dimethyl 4,5-dimethoxy-7-methyl-1-naphthylboronate | C15H19BO4 | 详情 | 详情 | |
| (XIX) | 38316 | 4,5-dimethoxy-7-methyl-1-naphthylboronic acid | C13H15BO4 | 详情 | 详情 | |
| (XX) | 38317 | 2,4-dibromophenyl methyl ether; 2,4-dibromo-1-methoxybenzene | 21702-84-1 | C7H6Br2O | 详情 | 详情 |
| (XXI) | 38318 | 4-bromo-1,3-cyclohexadien-5-yn-1-yl methyl ether; 1-bromo-4-methoxy-1,3-cyclohexadien-5-yne | C7H5BrO | 详情 | 详情 | |
| (XXII) | 37859 | C8H14LiNO | 详情 | 详情 |
合成路线6
该中间体在本合成路线中的序号：(II)Michael addition of 1-nitrohexane (I) to methyl crotonate (II) provided nitroester (III) as a mixture of diastereoisomers. Reduction and cyclization of (III) by hydrogenation over Raney Nickel gave the cis- (IV) and trans- (V) pyrrolidinones, which were separated by column chromatography. Racemic cis isomer (IV) was resolved upon condensation with (R)-(+)-1-naphythylethyl isocyanate (VI) in boiling benzene, followed by chromatographic separation of the resulting diastereomeric mixture of ureides. The desired isomer (VII) was then hydrolyzed with sodium butoxide in refluxing n-BuOH to furnish the (+)-cis pyrrolidinone (+)(IV). Subsequent treatment with trimethyloxonium tetrafluoborate produced the iminoether (VIII), which was finally reacted with NH4Cl in refluxing MeOH to provide the corresponding iminopyrrolidine.
| 【1】 Hagen, T.J.; Bergmanis, A.A.; Kramer, S.W.; Fok, K.F.; Schmelzer, A.E.; Pitzele, B.S.; Swenton, L.; Jerome, G.M.; Kornmeier, C.M.; Moore, W.M.; Branson, L.F.; Connor, J.R.; Manning, P.T.; Currie, M.G.; Hallinan, E.A.; 2-Iminopyrrolidines as potent and selective inhibitors of human inducible nitric oxide synthase. J Med Chem 1998, 41, 19, 3675. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 26801 | 1-nitrohexane | 646-14-0 | C6H13NO2 | 详情 | 详情 |
| (II) | 26361 | methyl (E)-2-butenoate | 623-43-8 | C5H8O2 | 详情 | 详情 |
| (III) | 26802 | methyl 3-methyl-4-nitrononanoate | C11H21NO4 | 详情 | 详情 | |
| (IV) | 26803 | (4R,5R)-4-methyl-5-pentyl-2-pyrrolidinone | C10H19NO | 详情 | 详情 | |
| (V) | 26804 | (4R,5S)-4-methyl-5-pentyl-2-pyrrolidinone | C10H19NO | 详情 | 详情 | |
| (VI) | 26805 | (1R)-1-(1-naphthyl)ethyl isocyanate | 42340-98-7 | C13H11NO | 详情 | 详情 |
| (VII) | 26806 | (2R,3R)-3-methyl-N-[(1R)-1-(1-naphthyl)ethyl]-5-oxo-2-pentyl-1-pyrrolidinecarboxamide | C23H30N2O2 | 详情 | 详情 | |
| (VIII) | 26807 | (2R,3R)-5-methoxy-3-methyl-2-pentyl-3,4-dihydro-2H-pyrrole | C11H21NO | 详情 | 详情 |