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【结 构 式】

【分子编号】26304

【品名】(2S)-2-[[(2S)-2-[(tert-butoxycarbonyl)amino]-4-methylpentanoyl](methyl)amino]-3-(1-methoxy-1H-indol-3-yl)propionic acid

【CA登记号】

【 分 子 式 】C24H35N3O6

【 分 子 量 】461.55852

【元素组成】C 62.45% H 7.64% N 9.1% O 20.8%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(XLIV)

Dipeptide (XLIV) was prepared by coupling N-Boc-L-leucine (XLII) with tryptophan derivative (XXII), followed by basic hydrolysis of the resulting dipeptide ester (XLIII). Dipeptides (XLIV) and (XLI) were then coupled in the presence of HATU to afford tetrapeptide (XLV), which was separated from minor amounts of a tryptophan-epimerized byproduct by semipreparative RP-HPLC. Tetrapeptide ester (XLV) was then hydrolyzed to acid (XLVI) with LiOH in aqueous tert-butanol.

1 Boger, D.L.; et al.; Total synthesis of HUN-7293. J Am Chem Soc 1999, 121, 26, 6197.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(XXII) 26283 methyl (2S)-3-(1-methoxy-1H-indol-3-yl)-2-(methylamino)propanoate C14H18N2O3 详情 详情
(XLI) 26302 methyl (2S)-2-[[(2S,4R)-2-amino-4-methyloctanoyl](methyl)amino]propanoate C14H28N2O3 详情 详情
(XLII) 23663 (2S)-2-[(tert-butoxycarbonyl)amino]-4-methylpentanoic acid;N-Boc-L-leucine C11H21NO4 详情 详情
(XLIII) 26303 methyl (2S)-2-[[(2S)-2-[(tert-butoxycarbonyl)amino]-4-methylpentanoyl](methyl)amino]-3-(1-methoxy-1H-indol-3-yl)propanoate C25H37N3O6 详情 详情
(XLIV) 26304 (2S)-2-[[(2S)-2-[(tert-butoxycarbonyl)amino]-4-methylpentanoyl](methyl)amino]-3-(1-methoxy-1H-indol-3-yl)propionic acid C24H35N3O6 详情 详情
(XLV) 26305 methyl (6S,9S,12S,15S)-6-isobutyl-9-[(1-methoxy-1H-indol-3-yl)methyl]-2,2,8,14,15-pentamethyl-12-[(2R)-2-methylhexyl]-4,7,10,13-tetraoxo-3-oxa-5,8,11,14-tetraazahexadecan-16-oate C38H61N5O8 详情 详情
(XLVI) 26308 N-(Tert-butoxycarbonyl)-L-leucyl-(N-alpha-methyl-N-1-methoxy)-L-tryptophyl-L-(2-amino-4(R)-methyloctanoyl)-(N-methyl)-L-alanine; N-(Tert-butoxycarbonyl)-L-leucyl-(N-alpha-methyl-N-1-methoxy)-L-tryptophyl-L-(2-amino-4(R)-methyloctanoyl)-(N-methyl)-L-alanine C37H59N5O8 详情 详情
Extended Information