|
【结 构 式】 
|
【分子编号】26127 【品名】ethyl 4-[3-(3,4-dihydroxybenzoyl)-1H-indol-1-yl]butanoate 【CA登记号】 |
【 分 子 式 】C21H21NO5 【 分 子 量 】367.40148 【元素组成】C 68.65% H 5.76% N 3.81% O 21.77% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(X)In a related procedure, dihydroxybenzoyl indole (X) was selectively alkylated at 4-hydroxyl group with alpha-bromo-p-xylene (IV) to provide ether (XI). Further alkylation of (XI) with 1-bromo-3-chloropropane gave (XII). Then, halogen displacement in (XII) by piperazine (VI) furnished the precursor ethyl ester (IX), which was finally hydrolyzed to the target carboxylic acid as above.
| 【1】 Sato, H.; et al.; Dual-acting agents with alpha1-adrenoceptor antagonistic and steroid 5 alpha-reductase inhibitory activities. Synthesis and evaluation of arylpiperazine derivatives. Bioorg Med Chem Lett 1999, 9, 11, 1553. |
| 【2】 Yoshida, K.; Kurimoto, T.; Takei, M.; Sato, H. (Zeria Pharmaceutical Co., Ltd.); Indole deriv. and medicine containing the same. EP 0753511; US 5760040; WO 9526955 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| 10358 | 1-Bromo-3-chloropropane | 109-70-6 | C3H6BrCl | 详情 | 详情 | |
| (IV) | 24623 | 1-(bromomethyl)-4-methylbenzene | 104-81-4 | C8H9Br | 详情 | 详情 |
| (VI) | 23055 | ethyl 2-(1-piperazinyl)phenyl ether; 1-(2-ethoxyphenyl)piperazine | C12H18N2O | 详情 | 详情 | |
| (IX) | 26126 | ethyl 4-(3-[3-[3-[4-(2-ethoxyphenyl)-1-piperazinyl]propoxy]-4-[(4-methylbenzyl)oxy]benzoyl]-1H-indol-1-yl)butanoate | C44H51N3O6 | 详情 | 详情 | |
| (X) | 26127 | ethyl 4-[3-(3,4-dihydroxybenzoyl)-1H-indol-1-yl]butanoate | C21H21NO5 | 详情 | 详情 | |
| (XI) | 26128 | ethyl 4-(3-[3-hydroxy-4-[(4-methylbenzyl)oxy]benzoyl]-1H-indol-1-yl)butanoate | C29H29NO5 | 详情 | 详情 | |
| (XII) | 26129 | ethyl 4-(3-[3-(3-chloropropoxy)-4-[(4-methylbenzyl)oxy]benzoyl]-1H-indol-1-yl)butanoate | C32H34ClNO5 | 详情 | 详情 |
Extended Information