【结 构 式】 |
【分子编号】25922 【品名】3-(4-methoxy-2-methylphenyl)-2,5-dimethylpyrazolo[1,5-a]pyrimidin-7-ol 【CA登记号】 |
【 分 子 式 】C16H17N3O2 【 分 子 量 】283.33 【元素组成】C 67.83% H 6.05% N 14.83% O 11.29% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号:(III)The cyclization of 5-amino-4-(4-methoxy-2-methylphenyl)-3-methylpyrazole with ethyl acetoacetate (II) in refluxing acetic acid gives 7-hydroxy-3-(4-methoxy-2-methylphenyl)-5-methylpyrazolo[1,5-a]pyrimidine (III), which is treated with POCl3 and diethylaniline in refluxing toluene yielding the corresponding chloro derivative (IV). Finally, this compound is treated with pentyl-3-amine in DMSO at 150 C.
【1】 Arvanitis, A.G.; Chorvat, R.J. (DuPont Pharmaceuticals Co.); Azolo triazines and pyrimidines. US 6124289; WO 9803510 . |
中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
---|---|---|---|---|---|---|
(I) | 25921 | 4-(4-methoxy-2-methylphenyl)-3-methyl-1H-pyrazol-5-amine; 4-(4-methoxy-2-methylphenyl)-3-methyl-1H-pyrazol-5-ylamine | C12H15N3O | 详情 | 详情 | |
(II) | 11819 | ethyl acetoacetate; ethyl 3-oxobutanoate;Acetoacetic ester;Ethyl beta-ketobutyrate;ethyl 3-oxobutyrate | 141-97-9 | C6H10O3 | 详情 | 详情 |
(III) | 25922 | 3-(4-methoxy-2-methylphenyl)-2,5-dimethylpyrazolo[1,5-a]pyrimidin-7-ol | C16H17N3O2 | 详情 | 详情 | |
(IV) | 25923 | 7-chloro-3-(4-methoxy-2-methylphenyl)-2,5-dimethylpyrazolo[1,5-a]pyrimidine; 4-(7-chloro-2,5-dimethylpyrazolo[1,5-a]pyrimidin-3-yl)-3-methylphenyl methyl ether | C16H16ClN3O | 详情 | 详情 | |
(V) | 25924 | 1-ethylpropylamine; 3-pentanamine | 616-24-0 | C5H13N | 详情 | 详情 |
Extended Information