5-amino-2-[(E)-2-(4-amino-2-sulfonatophenyl)ethenyl]benzenesulfonate -Drug Synthesis Database

【结构式】

【分子编号】25917

【品名】5-amino-2-[(E)-2-(4-amino-2-sulfonatophenyl)ethenyl]benzenesulfonate

【CA登记号】

【分子式】C₁₄H₁₂N₂O₆S₂

【分子量】368.39116

【元素组成】C 45.65% H 3.28% N 7.6% O 26.06% S 17.41%

与该中间体有关的原料药合成路线共 2 条

合成路线1 合成路线2

合成路线1

该中间体在本合成路线中的序号：(I)

The reaction of stilbenediamine (I) with cyanuryl chloride (II) in dioxane gives the bis triazine derivative (III), which is further condensed with the substituted 3-aminobenzenesulfonamide (IV) in DMSO. The preceding synthesis can also be performed using cyanuryl fluoride instead of cyanuryl chloride as before.

参考文献中间体

合成目标

【1】 Mitsner, B.; Ding, W.-D.; Krishnamurthy, G.; et al.; Novel and specific respiratory syncytial virus inhibitors that target virus fusion. J Med Chem 1998, 41, 15, 2671.
【2】 Ding, W.-D.; Gluzman, Y.; Morin, J.E.; Mitsner, B.; Ellestad, G.A.; Nikitenko, A.A.; O'Hara, B.M.; Larocque, J.P.; Raifeld, Y.E. (American Cyanamid Co.); Bis-aryloxy(amino)-triazinyl-oxy(amino)aryl derivs., their preparation and their use as antiviral agents. CA 2197393; EP 0795549; JP 1997309882; US 5852015 .

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	25917	5-amino-2-[(E)-2-(4-amino-2-sulfonatophenyl)ethenyl]benzenesulfonate		C₁₄H₁₂N₂O₆S₂	详情	详情
(II)	23813	2,4,6-Trichloro-s-triazine; Cyanuric chloride; Trichlorocyanidine; Tricyanogen chloride; 2,4,6-Trichloro-1,3,5-triazine	108-77-0	C₃Cl₃N₃	详情	详情
(III)	25918	5-[(4,6-dichloro-1,3,5-triazin-2-yl)amino]-2-((E)-2-[4-[(4,6-dichloro-1,3,5-triazin-2-yl)amino]-2-sulfonatophenyl]ethenyl)benzenesulfonate		C₂₀H₁₀Cl₄N₈O₆S₂	详情	详情
(IV)	25919	3-[(3-amino-3-oxopropyl)[(3-aminophenyl)sulfonyl]amino]propanamide		C₁₂H₁₈N₄O₄S	详情	详情

合成路线2

该中间体在本合成路线中的序号：(I)

The reaction of cyanuryl chloride (II) with the substituted 3-aminobenzenesulfonamide (IV) in dioxane gives the bissulfonamide (V), which is finally condensed with stilbenediamine in sulfolane (I).

参考文献中间体

合成目标

【1】 Ding, W.-D.; Gluzman, Y.; Morin, J.E.; Mitsner, B.; Ellestad, G.A.; Nikitenko, A.A.; O'Hara, B.M.; Larocque, J.P.; Raifeld, Y.E. (American Cyanamid Co.); Bis-aryloxy(amino)-triazinyl-oxy(amino)aryl derivs., their preparation and their use as antiviral agents. CA 2197393; EP 0795549; JP 1997309882; US 5852015 .

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	25917	5-amino-2-[(E)-2-(4-amino-2-sulfonatophenyl)ethenyl]benzenesulfonate		C₁₄H₁₂N₂O₆S₂	详情	详情
(II)	23813	2,4,6-Trichloro-s-triazine; Cyanuric chloride; Trichlorocyanidine; Tricyanogen chloride; 2,4,6-Trichloro-1,3,5-triazine	108-77-0	C₃Cl₃N₃	详情	详情
(IV)	25919	3-[(3-amino-3-oxopropyl)[(3-aminophenyl)sulfonyl]amino]propanamide		C₁₂H₁₈N₄O₄S	详情	详情
(V)	25920	3-[(3-amino-3-oxopropyl)[(3-[[4-(3-[[bis(3-amino-3-oxopropyl)amino]sulfonyl]anilino)-6-chloro-1,3,5-triazin-2-yl]amino]phenyl)sulfonyl]amino]propanamide		C₂₇H₃₄ClN₁₁O₈S₂	详情	详情

Extended Information