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【结 构 式】 
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【分子编号】25741 【品名】(3S,6R,7R,22R,23S,26S,36R,38aR)-28,30,32-Triallyloxy-6-[N-(allyloxycarbonyl)-N-methyl-D-leucylamino]-44-[2-O-[3-(allyloxycarbonylamino)-2,3,6-trideoxy-3-C-methyl-beta-L-glucopyranosyloxy]-3-(carbamoylmethyl)-10,19-dichloro-7,22-dihyroxy-2,3,4,5,6,7,23,24,25,26,36,37,38,38a-tetradecahydro-1H,22H-8,11:18,21-dietheno-23,36-(iminomethano)-13,16:31,35-dimetheno-[1,6,9]oxadiazacyclohexadecino[4,5-m][10,2,16]benzoxadiazacyclotetracosine-26-carboxylic acid allyl ester; (3S,6R,7R,22R,23S,26S,36R,38aR)-28,30,32-Triallyloxy-6-[N-(allyloxycarbonyl)-N-methyl-D-leucylamino]-44-[2-O-[3-(allyloxycarbonylamino)-2,3,6-trideoxy-3-C-methyl-beta-L-glucopyranosyloxy]-3-(carbamoylmethyl)-10,19-dichloro-7,22-dihyroxy-2,3,4,5,6,7,23,24,25,26,36,37,38,38a-tetradecahydro-1H,22H-8,11:18,21-dietheno-23,36-(iminomethano)-13,16:31,35-dimetheno-[1,6,9]oxadiazacyclohexadecino[4,5-m][10,2,16]benzoxadiazacyclotetracosine-26-carboxylic acid allyl ester 【CA登记号】 |
【 分 子 式 】C85H97Cl2N9O28 【 分 子 量 】1763.65444 【元素组成】C 57.89% H 5.54% Cl 4.02% N 7.15% O 25.4% |
合成路线1
该中间体在本合成路线中的序号：(XV)Subsequent deacetylation with hydrazine produced (XV), from which the allyl and allyloxycarbonyl groups were finally removed by treatment with tributyltin hydride and palladium catalyst.
| 【1】 Thompson, C.; et al.; Synthesis of vancomycin from the aglycon. J Am Chem Soc 1999, 121, 6, 1237. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (XIV) | 25740 | (3S,6R,7R,22R,23S,26S,36R,38aR)-7,22-Diacetoxy-28,30,32-triallyloxy-6-[N-(allyloxycarbonyl)-N-methyl-D-leucylamino]-3-(carbamoylmethyl)-10,19-dichloro-44-[3,4,6-tri-O-acetyl-2-O-[3-(allyloxycarbonylamino)-2,3,6,trideoxy-3-C-methyl-beta-L-glucopyranosyloxy]-2,3,4,5,6,7,23,24,25,26,36,37,38,38a-tetradecahydro-1H,22H-8,11:18,21-dietheno-23,36-(iminomethano)-13,16:31,35-dimetheno-[1,6,9]oxadiazacyclohexadecino[4,5-m][10,2,16]benzoxadiazacyclotetracosine-26-carboxylic acid allyl ester; (3S,6R,7R,22R,23S,26S,36R,38aR)-7,22-Diacetoxy-28,30,32-triallyloxy-6-[N-(allyloxycarbonyl)-N-methyl-D-leucylamino]-3-(carbamoylmethyl)-10,19-dichloro-44-[3,4,6-tri-O-acetyl-2-O-[3-(allyloxycarbonylamino)-2,3,6,trideoxy-3-C-methyl-beta-L-glucopyranosyloxy]-2,3,4,5,6,7,23,24,25,26,36,37,38,38a-tetradecahydro-1H,22H-8,11:18,21-dietheno-23,36-(iminomethano)-13,16:31,35-dimetheno-[1,6,9]oxadiazacyclohexadecino[4,5-m][10,2,16]benzoxadiazacyclotetracosine-26-carboxylic acid allyl ester | C96H109Cl2N9O32 | 详情 | 详情 | |
| (XV) | 25741 | (3S,6R,7R,22R,23S,26S,36R,38aR)-28,30,32-Triallyloxy-6-[N-(allyloxycarbonyl)-N-methyl-D-leucylamino]-44-[2-O-[3-(allyloxycarbonylamino)-2,3,6-trideoxy-3-C-methyl-beta-L-glucopyranosyloxy]-3-(carbamoylmethyl)-10,19-dichloro-7,22-dihyroxy-2,3,4,5,6,7,23,24,25,26,36,37,38,38a-tetradecahydro-1H,22H-8,11:18,21-dietheno-23,36-(iminomethano)-13,16:31,35-dimetheno-[1,6,9]oxadiazacyclohexadecino[4,5-m][10,2,16]benzoxadiazacyclotetracosine-26-carboxylic acid allyl ester; (3S,6R,7R,22R,23S,26S,36R,38aR)-28,30,32-Triallyloxy-6-[N-(allyloxycarbonyl)-N-methyl-D-leucylamino]-44-[2-O-[3-(allyloxycarbonylamino)-2,3,6-trideoxy-3-C-methyl-beta-L-glucopyranosyloxy]-3-(carbamoylmethyl)-10,19-dichloro-7,22-dihyroxy-2,3,4,5,6,7,23,24,25,26,36,37,38,38a-tetradecahydro-1H,22H-8,11:18,21-dietheno-23,36-(iminomethano)-13,16:31,35-dimetheno-[1,6,9]oxadiazacyclohexadecino[4,5-m][10,2,16]benzoxadiazacyclotetracosine-26-carboxylic acid allyl ester | C85H97Cl2N9O28 | 详情 | 详情 |