【结 构 式】 |
【分子编号】25685 【品名】(2S)-3-(acetoxy)-2-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]propionic acid 【CA登记号】 |
【 分 子 式 】C20H19NO6 【 分 子 量 】369.374 【元素组成】C 65.03% H 5.18% N 3.79% O 25.99% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号:(II)Coupling of (Z)-1-(3-amino-4-methoxyphenyl)-2-(3,4,5-trimethoxyphenyl)- ethene (I) with N-Fmoc-O-acetyl-L-serine (II) in the presence of DCC and HOBt provided the corresponding serineamide (III). Further deprotection of Fmoc and acetyl groups with NaOH furnished the title compound.
【1】 Hatanaka, T.; Ohsumi, K.; Tsuji, T.; Nihei, Y.; Nakagawa, R.; Ohishi, K. (Ajinomoto Co., Inc.); Stilbene derivs. and pharmaceutical compsns. containing them. CA 2171275; EP 0731085; JP 1996301831; US 5674906 . |
中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
---|---|---|---|---|---|---|
(I) | 18228 | 2-methoxy-5-[(Z)-2-(3,4,5-trimethoxyphenyl)ethenyl]aniline; 2-methoxy-5-[(Z)-2-(3,4,5-trimethoxyphenyl)ethenyl]phenylamine | C18H21NO4 | 详情 | 详情 | |
(II) | 25685 | (2S)-3-(acetoxy)-2-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]propionic acid | C20H19NO6 | 详情 | 详情 | |
(III) | 25686 | 9H-fluoren-9-ylmethyl (1S)-1-[(isopropenyloxy)methyl]-2-[2-methoxy-5-[(Z)-2-(3,4,5-trimethoxyphenyl)ethenyl]anilino]-2-oxoethylcarbamate | C39H40N2O8 | 详情 | 详情 |
Extended Information