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【结 构 式】 
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【分子编号】26054 【品名】diethyl 2-(1-cyano-3-methylbutyl)malonate 【CA登记号】 |
【 分 子 式 】C13H21NO4 【 分 子 量 】255.31408 【元素组成】C 61.16% H 8.29% N 5.49% O 25.07% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(XXI)3) The reaction of diethyl malonate (XVIII) with 3-methylbutanal (XIX) by means of dipropylamine in acetic acid gives the corresponding 2-(3-methylbutylidene)malonate derivative (XX), which is treated with KCN to yield the corresponding addition compound (XXI). The decarboxylative hydrolysis of (XXI) with KOH affords 3-cyano-5-methylhexanoic acid (XXII), which is reduced with H2 over Ni to yield racemic pregabalin (XXIII). Finally, this racemate is submitted to optical resolution with (S)-(+)-mandelic acid.
| 【1】 Bryans, J.S.; Wustrow, D.J.; 3-Substituted GABA analogs with central nervous system activity: A review. Med Res Rev 1999, 19, 2, 149. |
| 【2】 Newhouse, B.J.; Ibrahim, P.; Burgess, L.E.; et al.; Potent selective nonpeptidic inhibitors of human lung tryptase. Proc Natl Acad Sci USA 1999, 96, 15, 8348. |
| 【3】 Mulhern, T.; Sobieray, D.M.; Huckabee, B.K.; Grote, T.M.; Titus, R.D. (Pfizer Inc.); Method of making (S)-3-(aminomethyl)-5-methylhexanoic acid. WO 9640617 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (XVIII) | 16829 | Diethyl malonate | 105-53-3 | C7H12O4 | 详情 | 详情 |
| (XIX) | 26052 | 3-methylbutanal | 590-86-3 | C5H10O | 详情 | 详情 |
| (XX) | 26053 | diethyl 2-(3-methylbutylidene)malonate | C12H20O4 | 详情 | 详情 | |
| (XXI) | 26054 | diethyl 2-(1-cyano-3-methylbutyl)malonate | C13H21NO4 | 详情 | 详情 | |
| (XXII) | 26055 | 3-cyano-5-methylhexanoic acid | C8H13NO2 | 详情 | 详情 | |
| (XXIII) | 26056 | 3-(aminomethyl)-5-methylhexanoic acid | 130912-52-6 | C8H17NO2 | 详情 | 详情 |
Extended Information