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【结 构 式】 
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【分子编号】25983 【品名】ethyl 2-(4-[2-[[(4-fluoroanilino)carbonyl](heptyl)amino]ethyl]phenoxy)-2-methylpropanoate 【CA登记号】 |
【 分 子 式 】C28H39FN2O4 【 分 子 量 】486.6271432 【元素组成】C 69.11% H 8.08% F 3.9% N 5.76% O 13.15% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(XIV)The condensation of ethyl 2-[4-[2-(heptylamino)ethyl]phenoxy]-2-methylpropionate (XIII) with 4-fluorophenyl isocyanate (XI) gives the corresponding ureido compound (XIV), which is then hydrolyzed with NaOH in refluxing ethanol.
| 【1】 Brown, P.J.; et al.; Generation of secondary alkyl amines on solid support by borane reduction. Application to the parallel synthesis of PPAR ligands. Synthesis 1997, 7, 778. |
| 【2】 Willson, T.M. (Glaxo Group Ltd.); Use of agonists of the peroxisome proliferator activated receptor alpha for treating obesity. WO 9736579 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (XI) | 17977 | 1-Fluoro-4-isocyanatobenzene; 4-Fluorophenyl isocyanate | 1195-45-5 | C7H4FNO | 详情 | 详情 |
| (XIII) | 25982 | ethyl 2-[4-[2-(heptylamino)ethyl]phenoxy]-2-methylpropanoate | C21H35NO3 | 详情 | 详情 | |
| (XIV) | 25983 | ethyl 2-(4-[2-[[(4-fluoroanilino)carbonyl](heptyl)amino]ethyl]phenoxy)-2-methylpropanoate | C28H39FN2O4 | 详情 | 详情 |
Extended Information