合成路线1

Alternatively, pyrazole ester (IV) was hydrolyzed to carboxylic acid (IX) with NaOH in ethanol. Then, conversion of (IX) to acid chloride with SOCl2, followed by treatment with N,O-dimethylhydroxylamine provided N-methoxy amide (X). Subsequent coupling of (X) with bromide (V) in the presence of n-BuLi afforded ketone (VI). Oxazoline hydrolysis as before yielded acid (VII), which was protected as the methyl ester (XI) upon treatment with MeI and NaH. Ketalization of (XI) was carried out with trimethyl orthoformate in MeOH in the presence of p-TsOH yielding (XII), and the methyl ester function of (XII) was then hydrolyzed with NaOH to furnish acid (XIII). Finally, conversion to the target amide was effected by reaction with ammonia in the presence of EDC and HOBt.