benzyl (2S)-2-[[chloro(phenoxy)phosphoryl]amino]propanoate -Drug Synthesis Database

【结构式】

【分子编号】25326

【品名】benzyl (2S)-2-[[chloro(phenoxy)phosphoryl]amino]propanoate

【CA登记号】

【分子式】C₁₆H₁₇ClNO₄P

【分子量】353.741782

【元素组成】C 54.33% H 4.84% Cl 10.02% N 3.96% O 18.09% P 8.76%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(I)

Title phosphoramidate was obtained by condensation of phenyl [(1-naphthylmethoxy)alanino]phosphorochloridate (I) with 2',3'-dideoxy-2',3'-didehydrothymidine (II) in the presence of N-methylmorpholine in THF at r.t.

参考文献中间体

合成目标

【1】 McGuigan, C.; Sutton, P.W.; Cahard, D.; Turner, K.; O'Leary, G.; Wang, Y.; Gumbleton, M.; De Clercq, E.; Balzarini, J.; Synthesis, anti-human immunodeficiency virus activity and esterase lability of some novel carboxylic ester-modified phosphoramidate derivatives of stavudine (d4T). Antivir Chem Chemother 1998, 9, 6, 473.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	25326	benzyl (2S)-2-[[chloro(phenoxy)phosphoryl]amino]propanoate		C₁₆H₁₇ClNO₄P	详情	详情
(II)	25323	1-[(2R,5S)-5-(hydroxymethyl)-2,5-dihydro-2-furanyl]-5-methyl-2,4(1H,3H)-pyrimidinedione		C₁₀H₁₂N₂O₄	详情	详情

Extended Information