【结 构 式】 |
【分子编号】25214 【品名】2-propionyl-1-hydrazinecarbodithioate 【CA登记号】 |
【 分 子 式 】C4H7N2OS2 【 分 子 量 】163.24446 【元素组成】C 29.43% H 4.32% N 17.16% O 9.8% S 39.29% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号:(II)Reaction of propionic acid hydrazide (I) with CS-2 and KOH gave dithiocarbamate (II), which was cyclized to aminotriazole (III) upon treatment with hydrazine. Demethylation of podophyllotoxin (IV) with HBr, followed by treatment with BaCO3 afforded 4'-demethyl epipodophyllotoxin (V). Finally, condensation of (V) with triazole (III) in the presence of trifluoroacetic acid furnished the title compound.
【1】 Chen, Y.Z.; Lu, K.K.; Synthesis and antitumor activities of 4beta-S-(5''-alkyl-4''-amino-1'',2'',4''-triazole-3''-yl)-4-deoxy-4'-O-demethyl-epipodophyllotoxin derivatives. Acta Pharm Sin 1999, 34, 1, 63. |
中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
---|---|---|---|---|---|---|
(I) | 25213 | propanohydrazide | C3H8N2O | 详情 | 详情 | |
(II) | 25214 | 2-propionyl-1-hydrazinecarbodithioate | C4H7N2OS2 | 详情 | 详情 | |
(III) | 25215 | 4-amino-5-ethyl-4H-1,2,4-triazol-3-ylhydrosulfide; 4-amino-5-ethyl-4H-1,2,4-triazole-3-thiol | C4H8N4S | 详情 | 详情 | |
(IV) | 14608 | (5R,5aR,8aR,9R)-9-hydroxy-5-(3,4,5-trimethoxyphenyl)-5,8,8a,9-tetrahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6(5aH)-one; Podophyllotoxin | 518-28-5 | C22H22O8 | 详情 | 详情 |
(V) | 13053 | (5R,5aR,8aR,9S)-9-Hydroxy-5-(4-hydroxy-3,5-dimethoxyphenyl)-5,8,8a,9-tetrahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6(5aH)-one | 6559-91-7 | C21H20O8 | 详情 | 详情 |
Extended Information