【结 构 式】 |
【分子编号】25124 【品名】N-[2-(3,4-dichlorophenyl)-4-hydroxybutyl]-3,4,5-trimethoxy-N-methylbenzamide 【CA登记号】 |
【 分 子 式 】C21H25Cl2NO5 【 分 子 量 】442.33864 【元素组成】C 57.02% H 5.7% Cl 16.03% N 3.17% O 18.09% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号:(I)Treatment of alcohol (I) with methanesulfonyl chloride in the presence of triethylamine provided mesylate (II), which was condensed with the spirosubstituted piperidine (III) to give the desired compound.
【1】 Kubota, H.; Kakefuda, A.; Okamoto, Y.; Fujii, M.; Yamamoto, O.; Yamagiwa, Y.; Orita, M.; Ikeda, K.; Takeuchi, M.; Shibanuma, T.; Isomura, Y.; Spiro-substituted piperidines as neurokinin receptor antagonists. III. Synthesis of (±)-N-[2-(3,4-dichlorophenyl)-4-(spiro-substituted piperidin-1'-yl)butyl]-N-methylbenzamides and evaluation of NK1-NK2 dual antagonistic activities. Chem Pharm Bull 1998, 46, 10, 1538. |
中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
---|---|---|---|---|---|---|
(I) | 25124 | N-[2-(3,4-dichlorophenyl)-4-hydroxybutyl]-3,4,5-trimethoxy-N-methylbenzamide | C21H25Cl2NO5 | 详情 | 详情 | |
(II) | 25125 | 3-(3,4-dichlorophenyl)-4-[methyl(3,4,5-trimethoxybenzoyl)amino]butyl methanesulfonate | C22H27Cl2NO7S | 详情 | 详情 | |
(III) | 25126 | 1,2,3,4-tetrahydrospiro[isoquinoline-1,4'-piperidin]-3-one | C13H16N2O | 详情 | 详情 |
Extended Information