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【结 构 式】 
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【分子编号】25101 【品名】methyl 3-hydroxy-5-isoxazolecarboxylate 【CA登记号】10068-07-2 |
【 分 子 式 】C5H5NO4 【 分 子 量 】143.09904 【元素组成】C 41.97% H 3.52% N 9.79% O 44.72% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(X)The intermediate 3-(4-cyanobenzyloxy)isoxazole-5-carboxylic acid (VII) has been obtained by condensation of 4-(bromomethyl)benzonitrile (IX) with 3-hydroxyisoxazole-5-carboxylic acid methyl ester (X) by means of K2CO3 in hot DMF to yield the benzyloxy derivative (XI), which is finally hydrolyzed with LiOH in THF to provide the target intermediate (VII).
| 【1】 Xue, C.-B.; Roderick, J.; Mousa, S.; Olson, R.E.; DeGrado, W.F.; Synthesis and antiplatelet effects of an isoxazole series of glycoprotein IIb/IIIa antagonists. Bioorg Med Chem Lett 1998, 8, 24, 3499. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (VII) | 25098 | 3-[(4-cyanobenzyl)oxy]-5-isoxazolecarboxylic acid | C12H8N2O4 | 详情 | 详情 | |
| (IX) | 14200 | 4-(Bromomethyl)benzonitrile; alpha-Bromo-p-tolunitrile | 17201-43-3 | C8H6BrN | 详情 | 详情 |
| (X) | 25101 | methyl 3-hydroxy-5-isoxazolecarboxylate | 10068-07-2 | C5H5NO4 | 详情 | 详情 |
| (XI) | 25103 | N-omega'-nitro-D-arginine | C6H13N5O4 | 详情 | 详情 |
Extended Information