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【结 构 式】 
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【分子编号】25058 【品名】2-(methoxyimino)-2-[2-(tritylamino)-1,3-thiazol-4-yl]acetic acid 【CA登记号】64485-90-1 |
【 分 子 式 】C25H21N3O3S 【 分 子 量 】443.52616 【元素组成】C 67.7% H 4.77% N 9.47% O 10.82% S 7.23% |
合成路线1
该中间体在本合成路线中的序号：(III)The protection of the amino group of ethyl 2-(2-amino-4-thiazolyl)-2-methoxyiminoacetate (I) with trityl chloride (B) by means of triethylamine in CH2Cl2 gives ethyl 2-(2-tritylamino-4-thiazolyl)-2-methoxyimino acetate (II), which is hydrolyzed to the corresponding acid (III) with NaOH in refluxing dioxane-water. The condensation of (III) with 7-aminocephalosporanic acid (IV) by means of dicyclohexylcarbodiimide in CH2Cl2 containing triethylamine affords 7-(2-(2-tritylamino-4-thiazolyl)-2-methoxyiminoacetamido]cephalosporanic acid (V). The elimination of the trityl group is performed with hot 55% formic acid yielding the corresponding free acid, which is finally treated with NaHCO3 in water.
| 【1】 Neuman, M.; Castaner, J.; HR-756. Drugs Fut 1978, 3, 10, 749. |
| 【2】 Heymes, R.; Lutz, A. (Aventis Pharma SA); Oxime derivatives of 7-aminothiazolylacetamidocephalosporanic acid processes for preparing them and pharmaceutical compositions incorporating them. BE 0850662; ES 455089; ES 466539; GB 1580621; GB 1580623; JP 52102293; JP 5247013 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (A) | 10180 | Thiourea | 62-56-6 | CH4N2S | 详情 | 详情 |
| (B) | 28630 | Triphenylchloromethane; 1-[Chloro(diphenyl)methyl]benzene; Trityl chloride | 76-83-5 | C19H15Cl | 详情 | 详情 |
| (I) | 10182 | Ethyl 2-(2-aminothiazole-4-yl)-2-methoxyiminoacetate; ethyl 2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetate; 2-(2-Amino-4-thiazolyl)-2-methoxyiminoacetic acid ethyl ester | 64485-88-7 | C8H11N3O3S | 详情 | 详情 |
| (II) | 39963 | ethyl 2-(methoxyimino)-2-[2-(tritylamino)-1,3-thiazol-4-yl]acetate | C27H25N3O3S | 详情 | 详情 | |
| (III) | 25058 | 2-(methoxyimino)-2-[2-(tritylamino)-1,3-thiazol-4-yl]acetic acid | 64485-90-1 | C25H21N3O3S | 详情 | 详情 |
| (IV) | 22747 | (6R,7R)-3-[(acetoxy)methyl]-7-amino-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid | C10H12N2O5S | 详情 | 详情 | |
| (V) | 39964 | (6R,7R)-3-[(acetoxy)methyl]-7-([2-(methoxyimino)-2-[2-(tritylamino)-1,3-thiazol-4-yl]acetyl]amino)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid | C35H31N5O7S2 | 详情 | 详情 | |
| (VI) | 39961 | ethyl 4-chloro-2-(hydroxyimino)-3-oxobutanoate；(Z)-ethyl 4-chloro-2-(hydroxyimino)-3-oxobutanoate | C6H8ClNO4 | 详情 | 详情 | |
| (VII) | 39962 | ethyl 4-chloro-2-(methoxyimino)-3-oxobutanoate | C7H10ClNO4 | 详情 | 详情 | |
| (VIII) | 20853 | ethyl 2-(hydroxyimino)-3-oxobutanoate；(Z)-ethyl 2-(hydroxyimino)-3-oxobutanoate | C6H9NO4 | 详情 | 详情 | |
| (IX) | 20854 | ethyl 2-(methoxyimino)-3-oxobutanoate | C7H11NO4 | 详情 | 详情 | |
| (X) | 10181 | ethyl 4-bromo-2-(methoxyimino)-3-oxobutanoate | 60845-87-6 | C7H10BrNO4 | 详情 | 详情 |
合成路线2
该中间体在本合成路线中的序号：(I)The condensation of 2-(methoxyimino)-2-(2-tritylaminothiazol-4-yl)acetic acid (I) with 7-aminocephalosporanic acid (II) by means of dicyclohexylcarbodiimide in CH2Cl2 gives 7-[2-(methoxyimino)-2-(2-tritylaminothiazol-4-yl)acetamido]cephalosporanic acid (III), which is deprotected by means of formic acid in water yielding 7-[2-(methoxyimino)-2-(2-aminothiazol-4-yl)acetamido]cephalosporanic acid (IV). Finally, this compound is condensed with 5-(carboxymethyl)-2-mercapto-4-methyl-1,3-thiazole (V) by means of NaHCO3 or NaOH in hot water.
| 【1】 Wolff, S.; et al.; Results of a multicenter phase III trial of magnetic resonance angiography (MRA) with MS-325 for the detection of peripheral vascular disease in the aortolliac region. Circulation 2002, 106, 19, Suppl. 2, Abst 3408. |
| 【2】 Duerckeimer, W.; et al. (Aventis Pharma AG); Cephem derivative. BE 0865632; FR 2385722; GB 1604971; JP 5706887; US 4278793 . |
| 【3】 Serradell, M.N.; Castaner, J.; Cefodizime. Drugs Fut 1984, 9, 3, 177. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 25058 | 2-(methoxyimino)-2-[2-(tritylamino)-1,3-thiazol-4-yl]acetic acid | 64485-90-1 | C25H21N3O3S | 详情 | 详情 |
| (II) | 15672 | 7-Aminocephalosporanic acid; 3-[(acetoxy)methyl]-7-amino-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid; 7-ACA | C10H12N2O5S | 详情 | 详情 | |
| (III) | 30338 | 3-[(acetoxy)methyl]-7-([2-(methoxyimino)-2-[2-(tritylamino)-1,3-thiazol-4-yl]acetyl]amino)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid | 66254-46-4 | C35H31N5O7S2 | 详情 | 详情 |
| (IV) | 30339 | 3-[(acetoxy)methyl]-7-[[2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid | C16H17N5O7S2 | 详情 | 详情 | |
| (V) | 19846 | 2-(4-methyl-2-sulfanyl-1,3-thiazol-5-yl)acetic acid | 34272-64-5 | C6H7NO2S2 | 详情 | 详情 |
合成路线3
该中间体在本合成路线中的序号：(Ib)The cephalosporin was synthesized following the reaction pathway depicted in Scheme 25490101a: Protected 2-(2-aminothiazol-4-yl)-2-(alkoxy)iminoacetic acid ((Ia-c) was reacted with p-methoxybenzyl 7-amino-3-chloromethyl-cephaslosporonate (II) by a conventional method (POCl3, pyr / CH2Cl2. -5 C) to give the acylated product (IIIa-c). Product (IIIa-c) was then coverted to a phosponium salt (Iva-c) (PPh3, NaI / acetone, r.t.), followed by the reaction (NaHCO3(2N) / CH2Cl2, 0 C - r.t.) with a substituted isoxazole aldehyde (V) to afford the protected final product (Via-c). The aldehyde (V) was prepared by the sequential reduction-oxidation of the 1,3-dipolar cycloaddition product of methyl propiolate and the corresponding aldoxime. Deprotection, sodium salt formation and purification by reverse phase column chromatography (LiChrosorb(R) RP-18, 25% aq. MeOH) followed by frezee drying gave the final product as an amorphous white solid.
| 【1】 Choi, K.I.; Discovery of novel 3-isoxazolylvinylcephalosporins. Drugs Fut 1999, 24, 3, 287. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (Ia) | 25057 | 2-[2-(tritylamino)-1,3-thiazol-4-yl]-2-[(trityloxy)imino]acetic acid | C43H33N3O3S | 详情 | 详情 | |
| (Ib) | 25058 | 2-(methoxyimino)-2-[2-(tritylamino)-1,3-thiazol-4-yl]acetic acid | 64485-90-1 | C25H21N3O3S | 详情 | 详情 |
| (Ic) | 25059 | 2-[(cyclopentyloxy)imino]-2-[2-(tritylamino)-1,3-thiazol-4-yl]acetic acid | C29H27N3O3S | 详情 | 详情 | |
| (IIIa) | 25061 | 4-methoxybenzyl 3-(chloromethyl)-8-oxo-7-([2-[2-(tritylamino)-1,3-thiazol-4-yl]-2-[(trityloxy)imino]acetyl]amino)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate | C59H48ClN5O6S2 | 详情 | 详情 | |
| (IIIb) | 25062 | 4-methoxybenzyl 3-(chloromethyl)-7-([2-(methoxyimino)-2-[2-(tritylamino)-1,3-thiazol-4-yl]acetyl]amino)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate | C41H36ClN5O6S2 | 详情 | 详情 | |
| (IIIc) | 25063 | 4-methoxybenzyl 3-(chloromethyl)-7-([2-[(cyclopentyloxy)imino]-2-[2-(tritylamino)-1,3-thiazol-4-yl]acetyl]amino)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate | C45H42ClN5O6S2 | 详情 | 详情 | |
| (IVa) | 25064 | [[2-[[(4-methoxybenzyl)oxy]carbonyl]-8-oxo-7-([2-[2-(tritylamino)-1,3-thiazol-4-yl]-2-[(trityloxy)imino]acetyl]amino)-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]methyl](triphenyl)phosphonium iodide | C77H63IN5O6PS2 | 详情 | 详情 | |
| (IVb) | 25065 | [[2-[[(4-methoxybenzyl)oxy]carbonyl]-7-([2-(methoxyimino)-2-[2-(tritylamino)-1,3-thiazol-4-yl]acetyl]amino)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]methyl](triphenyl)phosphonium iodide | C59H51IN5O6PS2 | 详情 | 详情 | |
| (IVc) | 25066 | [(7-([2-[(cyclopentyloxy)imino]-2-[2-(tritylamino)-1,3-thiazol-4-yl]acetyl]amino)-2-[[(4-methoxybenzyl)oxy]carbonyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl)methyl](triphenyl)phosphonium iodide | C63H57IN5O6PS2 | 详情 | 详情 | |
| (VIa) | 25068 | 4-methoxybenzyl 3-[(E)-2-(3-chloro-5-isoxazolyl)ethenyl]-8-oxo-7-([2-[2-(tritylamino)-1,3-thiazol-4-yl]-2-[(trityloxy)imino]acetyl]amino)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate | C63H49ClN6O7S2 | 详情 | 详情 | |
| (VIb) | 25069 | 4-methoxybenzyl 3-[(E)-2-(3-chloro-5-isoxazolyl)ethenyl]-7-([2-(methoxyimino)-2-[2-(tritylamino)-1,3-thiazol-4-yl]acetyl]amino)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate | C45H37ClN6O7S2 | 详情 | 详情 | |
| (VIc) | 25070 | 4-methoxybenzyl 3-[(E)-2-(3-chloro-5-isoxazolyl)ethenyl]-7-([2-[(cyclopentyloxy)imino]-2-[2-(tritylamino)-1,3-thiazol-4-yl]acetyl]amino)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate | C49H43ClN6O7S2 | 详情 | 详情 | |
| (II) | 25060 | 4-methoxybenzyl 3-(chloromethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate | C16H16ClNO4S | 详情 | 详情 | |
| (V) | 25067 | 3-chloro-5-isoxazolecarbaldehyde | C4H2ClNO2 | 详情 | 详情 |
合成路线4
该中间体在本合成路线中的序号：(Ib)The cephalosporin was synthesized following the reaction pathway depicted in Scheme 25490201a: Protected 2-(2-aminothiazol-4-yl)-2-(alkoxy)iminoacetic acid ((Ia-c) was reacted with p-methoxybenzyl 7-amino-3-chloromethyl-cephaslosporonate (II) by a conventional method (POCl3, pyr / CH2Cl2. -5 C) to give the acylated product (IIIa-c). Product (IIIa-c) was then coverted to a phosponium salt (Iva-c) (PPh3, NaI / acetone, r.t.), followed by the reaction (NaHCO3(2N) / CH2Cl2, 0 C - r.t.) with a substituted isoxazole aldehyde (V) to afford the protected final product (Via-c). The aldehyde (V) was prepared by the sequential reduction-oxidation of the 1,3-dipolar cycloaddition product of methyl propiolate and the corresponding aldoxime. Deprotection, sodium salt formation and purification by reverse phase column chromatography (LiChrosorb(R) RP-18, 25% aq. MeOH) followed by frezee drying gave the final product as an amorphous white solid.
| 【1】 Choi, K.I.; Discovery of novel 3-isoxazolylvinylcephalosporins. Drugs Fut 1999, 24, 3, 287. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (Ia) | 25057 | 2-[2-(tritylamino)-1,3-thiazol-4-yl]-2-[(trityloxy)imino]acetic acid | C43H33N3O3S | 详情 | 详情 | |
| (Ib) | 25058 | 2-(methoxyimino)-2-[2-(tritylamino)-1,3-thiazol-4-yl]acetic acid | 64485-90-1 | C25H21N3O3S | 详情 | 详情 |
| (Ic) | 25059 | 2-[(cyclopentyloxy)imino]-2-[2-(tritylamino)-1,3-thiazol-4-yl]acetic acid | C29H27N3O3S | 详情 | 详情 | |
| (IIIa) | 25061 | 4-methoxybenzyl 3-(chloromethyl)-8-oxo-7-([2-[2-(tritylamino)-1,3-thiazol-4-yl]-2-[(trityloxy)imino]acetyl]amino)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate | C59H48ClN5O6S2 | 详情 | 详情 | |
| (IIIb) | 25062 | 4-methoxybenzyl 3-(chloromethyl)-7-([2-(methoxyimino)-2-[2-(tritylamino)-1,3-thiazol-4-yl]acetyl]amino)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate | C41H36ClN5O6S2 | 详情 | 详情 | |
| (IIIc) | 25063 | 4-methoxybenzyl 3-(chloromethyl)-7-([2-[(cyclopentyloxy)imino]-2-[2-(tritylamino)-1,3-thiazol-4-yl]acetyl]amino)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate | C45H42ClN5O6S2 | 详情 | 详情 | |
| (IVa) | 25064 | [[2-[[(4-methoxybenzyl)oxy]carbonyl]-8-oxo-7-([2-[2-(tritylamino)-1,3-thiazol-4-yl]-2-[(trityloxy)imino]acetyl]amino)-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]methyl](triphenyl)phosphonium iodide | C77H63IN5O6PS2 | 详情 | 详情 | |
| (IVb) | 25065 | [[2-[[(4-methoxybenzyl)oxy]carbonyl]-7-([2-(methoxyimino)-2-[2-(tritylamino)-1,3-thiazol-4-yl]acetyl]amino)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]methyl](triphenyl)phosphonium iodide | C59H51IN5O6PS2 | 详情 | 详情 | |
| (IVc) | 25066 | [(7-([2-[(cyclopentyloxy)imino]-2-[2-(tritylamino)-1,3-thiazol-4-yl]acetyl]amino)-2-[[(4-methoxybenzyl)oxy]carbonyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl)methyl](triphenyl)phosphonium iodide | C63H57IN5O6PS2 | 详情 | 详情 | |
| (VIa) | 25072 | 4-methoxybenzyl 3-[(E)-2-(3-methoxy-5-isoxazolyl)ethenyl]-8-oxo-7-([2-[2-(tritylamino)-1,3-thiazol-4-yl]-2-[(trityloxy)imino]acetyl]amino)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate | C64H52N6O8S2 | 详情 | 详情 | |
| (VIb) | 25073 | 4-methoxybenzyl 7-([2-(methoxyimino)-2-[2-(tritylamino)-1,3-thiazol-4-yl]acetyl]amino)-3-[(E)-2-(3-methoxy-5-isoxazolyl)ethenyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate | C46H40N6O8S2 | 详情 | 详情 | |
| (VIc) | 25074 | 4-methoxybenzyl 7-([2-[(cyclopentyloxy)imino]-2-[2-(tritylamino)-1,3-thiazol-4-yl]acetyl]amino)-3-[(E)-2-(3-methoxy-5-isoxazolyl)ethenyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate | C50H46N6O8S2 | 详情 | 详情 | |
| (II) | 25060 | 4-methoxybenzyl 3-(chloromethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate | C16H16ClNO4S | 详情 | 详情 | |
| (V) | 25071 | 3-methoxy-5-isoxazolecarbaldehyde | C5H5NO3 | 详情 | 详情 |
合成路线5
该中间体在本合成路线中的序号：(I)Trityl protected 2-(2-aminothiazol-4-yl)-2-(methoxy)iminoacetic acid (I) was coupled to 7-amino-3-(chloromethyl)cephalosporanic acid p-methoxybenzyl ester (II) using POCl3 and pyridine to give amide (III). This was converted to phosphonium salt (IV) upon treatment with triphenylphosphine and NaI. Subsequent Wittig reaction of (IV) with 3-chloroisoxazole-5-carbaldehyde (V) produced the corresponding vinyl isoxazole as a mixture of geometrical isomers, from which the major trans isomer (VI) was separated by flash column chromatography. Finally, deprotection of both trityl and p-methoxybenzyl groups of (VI) by means of trifluoroacetic acid afforded the title compound, which was isolated as the sodium salt.
| 【1】 Cho, Y.S.; Pae, A.N.; Cha, J.H.; Choi, K.I.; Chang, M.H.; Koh, H.Y.; Studies on novel 3-isoxazolylvinylcephalosporins: I. Synthesis and biological activity of 7-[2-(2-aminothiazol-4-yl)-2-(alkoxy)iminoacetamido] derivatives. J Antibiot 1998, 51, 12, 1117. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 25058 | 2-(methoxyimino)-2-[2-(tritylamino)-1,3-thiazol-4-yl]acetic acid | 64485-90-1 | C25H21N3O3S | 详情 | 详情 |
| (II) | 26869 | 4-methoxybenzyl 7-amino-3-(chloromethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate | C16H17ClN2O4S | 详情 | 详情 | |
| (III) | 25062 | 4-methoxybenzyl 3-(chloromethyl)-7-([2-(methoxyimino)-2-[2-(tritylamino)-1,3-thiazol-4-yl]acetyl]amino)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate | C41H36ClN5O6S2 | 详情 | 详情 | |
| (IV) | 25065 | [[2-[[(4-methoxybenzyl)oxy]carbonyl]-7-([2-(methoxyimino)-2-[2-(tritylamino)-1,3-thiazol-4-yl]acetyl]amino)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]methyl](triphenyl)phosphonium iodide | C59H51IN5O6PS2 | 详情 | 详情 | |
| (V) | 25067 | 3-chloro-5-isoxazolecarbaldehyde | C4H2ClNO2 | 详情 | 详情 | |
| (VI) | 26870 | 4-methoxybenzyl 3-[(E)-2-(3-chloro-5-isoxazolyl)ethenyl]-7-([2-(methoxyimino)-2-[2-(tritylamino)-1,3-thiazol-4-yl]acetyl]amino)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate | C45H37ClN6O7S2 | 详情 | 详情 |
合成路线6
该中间体在本合成路线中的序号：(II)Coupling of carboxylic acid (II) to the 7-aminocephem derivative (I) using POCl3 and pyridine produced the corresponding amide (III). Displacement of the chloro group of (III) with triphenyl phosphine furnished the phosphonium salt (IV), which was subjected to a Wittig reaction with chloroacetaldehyde (V), yielding the Z-propenyl chloride (VI). Subsequent reaction of allyl chloride (VI) with 4-amino-2-mercapto-6-methylpyrimidine (VII) in the presence of NaI produced the E-propenyl sulfide (VIII). The N-trityl group and the p-methoxybenzyl ester of (VIII) were finally cleaved by treatment with trifluoroacetic acid in anisole to furnish the title compound.
| 【1】 Lee, C.-S.; et al.; Synthesis and antibacterial activities of novel C(3)-aminopyrimidinyl substituted cephalosporins. J Antibiot 2000, 53, 11, 1305. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 26869 | 4-methoxybenzyl 7-amino-3-(chloromethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate | C16H17ClN2O4S | 详情 | 详情 | |
| (II) | 25058 | 2-(methoxyimino)-2-[2-(tritylamino)-1,3-thiazol-4-yl]acetic acid | 64485-90-1 | C25H21N3O3S | 详情 | 详情 |
| (III) | 25062 | 4-methoxybenzyl 3-(chloromethyl)-7-([2-(methoxyimino)-2-[2-(tritylamino)-1,3-thiazol-4-yl]acetyl]amino)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate | C41H36ClN5O6S2 | 详情 | 详情 | |
| (IV) | 47060 | [[2-[[(4-methoxybenzyl)oxy]carbonyl]-7-([2-(methoxyimino)-2-[2-(tritylamino)-1,3-thiazol-4-yl]acetyl]amino)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]methyl](triphenyl)phosphonium chloride | C59H51ClN5O6PS2 | 详情 | 详情 | |
| (V) | 47061 | 2-chloroacetaldehyde | 107-20-0 | C2H3ClO | 详情 | 详情 |
| (VI) | 47062 | 4-methoxybenzyl 3-[(Z)-3-chloro-1-propenyl]-7-([2-(methoxyimino)-2-[2-(tritylamino)-1,3-thiazol-4-yl]acetyl]amino)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate | C43H38ClN5O6S2 | 详情 | 详情 | |
| (VII) | 47063 | 2-amino-6-methyl-4-pyrimidinethiol; 2-amino-6-methyl-4-pyrimidinylhydrosulfide | C5H7N3S | 详情 | 详情 | |
| (VIII) | 47064 | 4-methoxybenzyl 3-[(E)-3-[(2-amino-6-methyl-4-pyrimidinyl)sulfanyl]-1-propenyl]-7-([2-(methoxyimino)-2-[2-(tritylamino)-1,3-thiazol-4-yl]acetyl]amino)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate | C48H44N8O6S3 | 详情 | 详情 |