【结 构 式】 |
【分子编号】24800 【品名】ethyl 4-(4-methylcyclohexyl)-4-oxobutanoate 【CA登记号】 |
【 分 子 式 】C13H22O3 【 分 子 量 】226.31588 【元素组成】C 68.99% H 9.8% O 21.21% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号:(V)The reaction of di-tert-butyl malonate (I) with ethyl 2-bromoacetate (II) by means of NaH in THF gives di-tert-butyl 2-(ethoxycarbonylmethyl)malonate (III), which is condensed with trans-4-methylcyclohexylcarbonyl chloride (IV) by means of NaH in THF, and without isolation is treated with p-toluenesulfonic acid in refluxing toluene to afford trans-4-(4-methylcyclohexyl)-4-oxobutyric acid ethyl ester (V). Finally, this compound is hydrolyzed with aqueous NaOH.
【1】 Shinkai, H.; Ozeki, H.; Motomura, T.; Ohta, T.; Furukawa, N.; Uchida, I.; 4-(trans-4-Methylcyclohexyl)-4-oxobutyric acid (JTT-608). A new class of antidiabetic agent. J Med Chem 1998, 41, 27, 5420. |
中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
---|---|---|---|---|---|---|
(I) | 14346 | di(tert-butyl) malonate; Di-tert-butyl malonate | 541-16-2 | C11H20O4 | 详情 | 详情 |
(II) | 16640 | Ethyl 2-bromoacetate; Ethyl bromoacetate | 105-36-2 | C4H7BrO2 | 详情 | 详情 |
(III) | 24798 | 1,1-di(tert-butyl) 2-ethyl 1,1,2-ethanetricarboxylate | C15H26O6 | 详情 | 详情 | |
(IV) | 24799 | 4-methylcyclohexanecarbonyl chloride | C8H13ClO | 详情 | 详情 | |
(V) | 24800 | ethyl 4-(4-methylcyclohexyl)-4-oxobutanoate | C13H22O3 | 详情 | 详情 |
Extended Information