1,6-bis([[[[amino(imino)methyl]amino](imino)methyl]amino]oxy)hexane -Drug Synthesis Database

【结构式】

【分子编号】24789

【品名】1,6-bis([[[[amino(imino)methyl]amino](imino)methyl]amino]oxy)hexane

【CA登记号】

【分子式】C₁₀H₂₄N₁₀O₂

【分子量】316.36676

【元素组成】C 37.97% H 7.65% N 44.27% O 10.11%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(XIII)

The reaction of benzohydroxamic acid (I) with 1,6-dibromohexane (X) by means of NaOH in methanol gives the bis benzohydroxamic ester (XI), which is treated with HCl to afford the subituted bis hydroxylamine (XII). The reaction of (XII) with dicyandiamide (V) in ethanol yields the bis biguanide (XIII), which is finally cyclized with cyclopentanone (VII) and HCl as before.

参考文献中间体

合成目标

【1】 Zhang, X.P.; Shen, J.; Xin, Z.M.; Qiu, Q.P.; Zhou, W.C.; Synthesis and antiprotozoal activities of some new triazine derivatives including a new antitrypanosomal agent: SIPI-1029. Acta Pharm Sin 1996, 31, 11, 823.
【2】 Zhou, W.; Zhang, X.; Trybizine Hydrochloride. Drugs Fut 1999, 24, 10, 1084.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	24777	N-hydroxybenzamide	495-18-1	C₇H₇NO₂	详情	详情
(V)	23611	N-cyanoguanidine	461-58-5	C₂H₄N₄	详情	详情
(VII)	15113	cyclopentanone	120-92-3	C₅H₈O	详情	详情
(X)	24786	1,6-dibromohexane	629-03-8	C₆H₁₂Br₂	详情	详情
(XI)	24787	N-([6-[(benzoylamino)oxy]hexyl]oxy)benzamide		C₂₀H₂₄N₂O₄	详情	详情
(XII)	24788	1,6-bis(aminooxy)hexane		C₆H₁₆N₂O₂	详情	详情
(XIII)	24789	1,6-bis([[[[amino(imino)methyl]amino](imino)methyl]amino]oxy)hexane		C₁₀H₂₄N₁₀O₂	详情	详情

Extended Information