N-(2-chloroethyl)-N'-[[(2R,3S,4S,5R,6S)-3,4,5-trihydroxy-6-methoxytetrahydro-2H-pyran-2-yl]methyl]urea -Drug Synthesis Database

【结构式】

【分子编号】24332

【品名】N-(2-chloroethyl)-N'-[[(2R,3S,4S,5R,6S)-3,4,5-trihydroxy-6-methoxytetrahydro-2H-pyran-2-yl]methyl]urea

【CA登记号】

【分子式】C₁₀H₁₉ClN₂O₆

【分子量】298.72344

【元素组成】C 40.21% H 6.41% Cl 11.87% N 9.38% O 32.14%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(IV)

2) The condensation of compound (I) with 2-chloroethyl isocyanate (III) by means of silver carbonate in acetonitrile water gives methyl 6-[[-(2-chloroethyl) amino]carbonylamino]-6-deoxy-alpha-D-glucopyranoside (IV), which is then nitrosated with NaNO2 in aqueous acetic acid

参考文献中间体

合成目标

【1】 Kimura, G.; Sekine, J. (Tokyo Tanabe Co., Ltd.); Alkyl amino-glucopyranoside derivative and process for producing the same. CA 1044228; CH 610334; DE 2530416; FR 2276828; GB 1499760; JP 7606925; JP 77125126; JP 7797915; NL 7507973 .
【2】 Prous, J.; Castaner, J.; Ranimustine. Drugs Fut 1986, 11, 9, 762.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	24328	(2R,3S,4S,5R,6S)-2-(aminomethyl)-6-methoxytetrahydro-2H-pyran-3,4,5-triol		C₇H₁₅NO₅	详情	详情
(III)	11237	1-Chloro-2-isocyanatoethane; 2-Chloroethyl isocyanate	1943-83-5	C₃H₄ClNO	详情	详情
(IV)	24332	N-(2-chloroethyl)-N'-[[(2R,3S,4S,5R,6S)-3,4,5-trihydroxy-6-methoxytetrahydro-2H-pyran-2-yl]methyl]urea		C₁₀H₁₉ClN₂O₆	详情	详情

Extended Information